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Disrupted small-world networks in schizophrenia

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WOS被引频次:568
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成果类型:
期刊论文
作者:
Liu, Yong;Liang, Meng;Zhou, Yuan;He, Yong;Hao, Yihui;Song, Ming;Yu, Chunshui;Liu, Haihong;Liu, Zhening;Jiang, Tianzi
通讯作者:
Jiang, TZ
作者机构:
[Hao, Yihui; Liu, Haihong; Liu, Zhening] Cent S Univ, Xiangya Hosp 2, Inst Mental Hlth, Changsha 410011, Hunan, Peoples R China.
[Zhou, Yuan; He, Yong; Liu, Yong; Song, Ming; Jiang, Tianzi; Liang, Meng] Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China.
[He, Yong] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ H3A 2B4, Canada.
[Yu, Chunshui] Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China.
[Liang, Meng] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3QX, England.
通讯机构:
[Jiang, TZ] Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China.
语种:
英文
关键词:
efficient small-world;brain functional networks;functional connectivity;resting-state fMRI;schizophrenia
期刊:
Brain : a journal of neurology
ISSN:
0006-8950
年:
2008
卷:
131
期:
04
页码:
945-961
文献类别:
WOS:Article
所属学科:
ESI学科类别:神经系统学&行为学;WOS学科类别:Clinical Neurology;Neurosciences
入藏号:
WOS:000254682300008;PMID:18299296
机构署名:
本校为其他机构
院系归属:
基础医学院
物理与电子学院
信息科学与工程学院
湘雅医院(第一临床学院)
湘雅二医院(第二临床学院)
摘要:
The human brain has been described as a large, sparse, complex network characterized by efficient small-world properties, which assure that the brain generates and integrates information with high efficiency. Many previous neuroimaging studies have provided consistent evidence of 'dysfunctional connectivity' among the brain regions in schizophrenia; however, little is known about whether or not this dysfunctional connectivity causes disruption of the topological properties of brain functional networks. To this end, we investigated the topological properties of human brain functional networks derived from resting-state functional magnetic resonance imaging (fMRI). Data was obtained from 31 schizophrenia patients and 31 healthy subjects; then functional connectivity between 90 cortical and sub-cortical regions was estimated by partial correlation analysis and thresholded to construct a set of undirected graphs. Our findings demonstrated that the brain functional networks had efficient small-world properties in the healthy subjects; whereas these properties were disrupted in the patients with schizophrenia. Brain functional networks have efficient small-world properties which support efficient parallel information transfer at a relatively low cost. More importantly, in patients with schizophrenia the small-world topological properties are significantly altered in many brain regions in the prefrontal, parietal and temporal lobes. These findings are consistent with a hypothesis of dysfunctional integration of the brain in this illness. Specifically, we found that these altered topological measurements correlate with illness duration in schizophrenia. Detection and estimation of these alterations could prove helpful for understanding the pathophysiological mechanism as well as for evaluation of the severity of schizophrenia.
参考文献:
Greicius MD, 2003, P NATL ACAD SCI USA, V100, P253, DOI 10.1073/pnas.0135058100
Honea R, 2005, AM J PSYCHIAT, V162, P2233, DOI 10.1176/appi.ajp.162.12.2233
Sporns O, 2004, NEUROINFORMATICS, V2, P145, DOI 10.1385/NI:2:2:145
Garrity AG, 2007, AM J PSYCHIAT, V164, P450, DOI 10.1176/appi.ajp.164.3.450
Latora V, 2003, EUR PHYS J B, V32, P249, DOI 10.1140/epjb/e2003-00095-5

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