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A review of biotransformation and pharmacology of ginsenoside compound K

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WOS被引频次:69
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成果类型:
期刊论文
作者:
Yang, Xi-Ding;Yang, Yong-Yu;Ouyang, Dong-Sheng;Yang, Guo-Ping*
通讯作者:
Yang, Guo-Ping
作者机构:
[Yang, Xi-Ding; Yang, Guo-Ping] Cent S Univ, Xiangya Hosp 3, Ctr Clin Pharmacol, Changsha 410013, Hunan, Peoples R China.
[Yang, Xi-Ding; Yang, Yong-Yu] Cent S Univ, Sch Pharmaceut Sci, Changsha 410013, Hunan, Peoples R China.
[Ouyang, Dong-Sheng] Cent S Univ, Inst Clin Pharmacol, Changsha 410078, Hunan, Peoples R China.
通讯机构:
[Yang, Guo-Ping] Cent S Univ, Xiangya Hosp 3, Ctr Clin Pharmacol, Changsha 410013, Hunan, Peoples R China.
语种:
英文
关键词:
Ginsenoside compound K;Ginseng;Biotransformation;Pharmacological activities
期刊:
Fitoterapia
ISSN:
0367-326X
年:
2015
卷:
100
页码:
208-220
文献类别:
WOS:Review
所属学科:
ESI学科类别:药理学&毒理学;WOS学科类别:Chemistry, Medicinal;Pharmacology & Pharmacy
入藏号:
基金类别:
National Science and Technology Major Projects for Major New Drugs Innovation and Development [2012ZX09303014-001]; Natural Science Foundation of Hunan Province [2014FJ3130]; Fundamental Research Funds for the Central Universities of Central South University [2013zzts292]
机构署名:
本校为第一且通讯机构
院系归属:
湘雅药学院
湘雅三医院(第三临床学院)
摘要:
As an intestinal bacterial metabolite of ginseng protopanaxadiol saponins, ginsenoside compound K (20-O-beta-o-glucopyranosyl-20(S)-protopanaxadiol, CK) is a major deglycosylated metabolite form of ginsenosides which is absorbed into the systemic circulation. And it has demonstrated such diverse intriguing biological properties as anticarcinogenic, anti-inflammation, antiallergic, anti-diabetic, anti-angiogenesis, anti-aging, neuroprotective and hepatoprotective effects. The present review shall summarize recent studies on various biotransformation and pharmacological activities of CIC. (C) 2014 Elsevier B.V. All rights reserved.
参考文献:
Akao T, 1998, BIOL PHARM BULL, V21, P245
Akao T, 1998, J PHARM PHARMACOL, V50, P1155, DOI 10.1111/j.2042-7158.1998.tb03327.x
An DS, 2010, APPL ENVIRON MICROB, V76, P5827, DOI 10.1128/AEM.00106-10
[Anonymous], PREPARATION METHOD L, Patent No. CNO3134090.3
Bae EA, 2005, BIOL PHARM BULL, V28, P1903, DOI 10.1248/bpb.28.1903

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