版权说明 帮助中心
首页 > 成果 > 详情

Let-7 in Cardiovascular Diseases, Heart Development and Cardiovascular Differentiation from Stem Cells

SCI-EMedline
WOS被引频次:71
认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Bao, Mei-Hua;Feng, Xing;Zhang, Yi-Wen;Lou, Xiao-Ya;Cheng, Yu;Zhou, Hong-Hao*
通讯作者:
Zhou, Hong-Hao
作者机构:
[Zhang, Yi-Wen; Cheng, Yu; Zhou, Hong-Hao; Lou, Xiao-Ya; Bao, Mei-Hua] Cent S Univ, Inst Clin Pharmacol, Changsha 410078, Hunan, Peoples R China.
[Bao, Mei-Hua] Changsha Med Univ, Dept Pharm, Changsha 410219, Hunan, Peoples R China.
[Feng, Xing] Hunan Normal Univ, Coll Med, Changsha 410006, Hunan, Peoples R China.
通讯机构:
[Zhou, Hong-Hao] Cent S Univ, Inst Clin Pharmacol, Changsha 410078, Hunan, Peoples R China.
语种:
英文
关键词:
let-7;cardiovascular disease;cardiovascular differentiation;heart development;biomarker
期刊:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN:
1422-0067
年:
2013
卷:
14
期:
11
页码:
23086-102
文献类别:
WOS:Review
所属学科:
ESI学科类别:化学;WOS学科类别:Biochemistry & Molecular Biology;Chemistry, Multidisciplinary
入藏号:
基金类别:
National Natural Sciences Foundation of China [81300231]; Hunan Provincial Natural Sciences Foundation of China [13JJ4112]; Hunan Provincial Innovation Foundation for Postgraduate [CX2013B101]; Hunan Provincial Department of Education Program [11Co152]
机构署名:
本校为第一且通讯机构
院系归属:
湘雅药学院
摘要:
The let-7 family is the second microRNA found in C. elegans. Recent researches have found it is highly expressed in the cardiovascular system. Studies have revealed the aberrant expression of let-7 members in cardiovascular diseases, such as heart hypertrophy, cardiac fibrosis, dilated cardiomyopathy (DCM), myocardial infarction (MI), arrhythmia, angiogenesis, atherosclerosis, and hypertension. Let-7 also participates in cardiovascular differentiation of embryonic stem cells. TLR4, LOX-1, Bcl-xl and AGO1 are by now the identified target genes of let-7. The circulating let-7b is suspected to be the biomarker of acute MI and let-7i, the biomarker of DCM. Further studies are necessary for identifying the gene targets and signaling pathways of let-7 in cardiovascular diseases. Let-7 might be a potential therapeutic target for cardiovascular diseases. This review focuses on the research progresses regarding the roles of let-7 in cardiovascular development and diseases.
参考文献:
Ago T, 2007, ANTIOXID REDOX SIGN, V9, P679, DOI 10.1089/ars.2007.1529
Ahmed RPH, 2011, CIRC RES, V109, P60, DOI 10.1161/CIRCRESAHA.110.240010
Arciniegas E, 2007, AM J PHYSIOL-LUNG C, V293, pL1, DOI 10.1152/ajplung.00378.2006
Bae ON, 2013, ARTERIOSCL THROM VAS, V33, P1920, DOI 10.1161/ATVBAHA.113.301609
Bartel DP, 2004, CELL, V116, P281, DOI 10.1016/S0092-8674(04)00045-5

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com