版权说明 帮助中心
首页 > 成果 > 详情

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

ESI高被引SCI-EMedline
WOS被引频次:564
认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Han, Jian-Wen;Zheng, Hou-Feng;Cui, Yong;Sun, Liang-Dan;Ye, Dong-Qing;Hu, Zhi;Xu, Jin-Hua;Cai, Zhi-Ming;Huang, Wei;Zhao, Guo-Ping;Xie, Hong-Fu;Fang, Hong;Lu, Qian-Jin;Xu, Jian-Hua;Li, Xiang-Pei;Pan, Yun-Feng;Deng, Dan-Qi;Zeng, Fan-Qin;Ye, Zhi-Zhong;Zhang, Xiao-Yan;Wang, Qing-Wen;Hao, Fei;Ma, Li;Zuo, Xian-Bo;Zhou, Fu-Sheng;Du, Wen-Hui;Cheng, Yi-Lin;Yang, Jian-Qiang;Shen, Song-Ke;Li, Jian;Sheng, Yu-Jun;Zuo, Xiao-Xia;Zhu, Wei-Fang;Gao, Fei;Zhang, Pei-Lian;Guo, Qing;Li, Bo;Gao, Min;Xiao, Feng-Li;Quan, Cheng;Zhang, Chi;Zhang, Zheng;Zhu, Kun-Ju;Li, Yang;Hu, Da-Yan;Lu, Wen-Sheng;Huang, Jian-Lin;Liu, Sheng-Xiu;Li, Hui;Ren, Yun-Qing;Wang, Zai-Xing;Yang, Chun-Jun;Wang, Pei-Guang;Zhou, Wen-Ming;Lv, Yong-Mei;Zhang, An-Ping;Zhang, Sheng-Quan;Lin, Da;Li, Yi;Low, Hui Qi;Shen, Min;Zhai, Zhi-Fang;Wang, Ying;Zhang, Feng-Yu;Yang, Sen;Liu, Jian-Jun;Zhang, Xue-Jun*
通讯作者:
Zhang, Xue-Jun
作者机构:
[Yang, Chun-Jun; Zheng, Hou-Feng; Ren, Yun-Qing; Wang, Zai-Xing; Zhu, Kun-Ju; Wang, Pei-Guang; Zhang, Zheng; Zhang, Xue-Jun; Zhou, Wen-Ming; Lv, Yong-Mei; Lu, Wen-Sheng; Ye, Dong-Qing; Quan, Cheng; Zuo, Xian-Bo; Han, Jian-Wen; Shen, Song-Ke; Lin, Da; Liu, Sheng-Xiu; Zhang, Sheng-Quan; Hu, Zhi; Gao, Min; Du, Wen-Hui; Xiao, Feng-Li; Yang, Jian-Qiang; Yang, Sen; Zhang, An-Ping; Zhou, Fu-Sheng; Sheng, Yu-Jun; Zhang, Chi; Zhang, Feng-Yu; Sun, Liang-Dan; Li, Jian; Hu, Da-Yan; Li, Hui; Liu, Jian-Jun; Cui, Yong; Li, Yang; Cheng, Yi-Lin] Anhui Med Univ, Hosp 1, Inst Dermatol, Hefei, Anhui, Peoples R China.
[Yang, Chun-Jun; Zheng, Hou-Feng; Ren, Yun-Qing; Wang, Zai-Xing; Zhu, Kun-Ju; Wang, Pei-Guang; Zhang, Zheng; Zhang, Xue-Jun; Zhou, Wen-Ming; Lv, Yong-Mei; Lu, Wen-Sheng; Ye, Dong-Qing; Quan, Cheng; Zuo, Xian-Bo; Han, Jian-Wen; Shen, Song-Ke; Lin, Da; Liu, Sheng-Xiu; Zhang, Sheng-Quan; Hu, Zhi; Gao, Min; Du, Wen-Hui; Xiao, Feng-Li; Yang, Jian-Qiang; Yang, Sen; Zhang, An-Ping; Zhou, Fu-Sheng; Sheng, Yu-Jun; Zhang, Chi; Zhang, Feng-Yu; Sun, Liang-Dan; Li, Jian; Hu, Da-Yan; Li, Hui; Liu, Jian-Jun; Cui, Yong; Li, Yang; Cheng, Yi-Lin] Anhui Med Univ, Hosp 1, Dept Dermatol, Hefei, Anhui, Peoples R China.
[Yang, Chun-Jun; Zheng, Hou-Feng; Ren, Yun-Qing; Wang, Zai-Xing; Zhu, Kun-Ju; Wang, Pei-Guang; Zhang, Zheng; Zhang, Xue-Jun; Zhou, Wen-Ming; Lv, Yong-Mei; Lu, Wen-Sheng; Ye, Dong-Qing; Quan, Cheng; Zuo, Xian-Bo; Han, Jian-Wen; Shen, Song-Ke; Lin, Da; Liu, Sheng-Xiu; Zhang, Sheng-Quan; Hu, Zhi; Gao, Min; Du, Wen-Hui; Xiao, Feng-Li; Yang, Jian-Qiang; Yang, Sen; Zhang, An-Ping; Zhou, Fu-Sheng; Sheng, Yu-Jun; Zhang, Chi; Zhang, Feng-Yu; Sun, Liang-Dan; Li, Jian; Hu, Da-Yan; Li, Hui; Liu, Jian-Jun; Cui, Yong; Li, Yang; Cheng, Yi-Lin] Anhui Med Univ, Minist Educ, Key Lab Dermatol, Hefei, Anhui, Peoples R China.
[Zhang, Xue-Jun; Xu, Jin-Hua] Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai 200433, Peoples R China.
[Cai, Zhi-Ming; Wang, Qing-Wen] Peking Univ, Shenzhen Hosp, Dept Rheumatol, Shenzhen, Guangdong, Peoples R China.
通讯机构:
[Zhang, Xue-Jun] Anhui Med Univ, Hosp 1, Inst Dermatol, Hefei, Anhui, Peoples R China.
语种:
英文
期刊:
Nature Genetics
ISSN:
1061-4036
年:
2009
卷:
41
期:
11
页码:
1234-1237
文献类别:
WOS:Article
所属学科:
ESI学科类别:分子生物学&遗传学;WOS学科类别:Genetics & Heredity
入藏号:
基金类别:
National Natural Science Foundation [30972727, 30530670, 30830089]; Anhui Provincial Special Scientific Program [2007-7]; Anhui Skin Genetic Study Innovative Research Team Program [TD200701]
机构署名:
本校为其他机构
院系归属:
湘雅医院(第一临床学院)
湘雅二医院(第二临床学院)
摘要:
We performed a genome-wide association study (GWAS) of systemic lupus erythematosus (SLE) in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using Illumina Human610-Quad BeadChips and replicating 78 SNPs in two additional cohorts (3,152 cases and 7,050 controls). We identified nine new susceptibility loci (ETS1, IKZF1, RASGRP3, SLC15A4, TNIP1, 7q11.23, 10q11.22, 11q23.3 and 16p11.2; 1.77 x 10(-25) < or = P(combined) < or = 2.77 x 10(-8)) and confirmed seven previously reported loci (BLK, IRF5, STAT4, TNFAIP3, TNFSF4, 6q21 and 22q11.21; 5.17 x 10(-42) < or = P(combined) < or = 5.18 x 10(-12)). Comparison with previous GWAS findings highlighted the genetic heterogeneity of SLE susceptibility between Chinese Han and European populations. This study not only advances our understanding of the genetic basis of SLE but also highlights the value of performing GWAS in diverse ancestral populations.
参考文献:
Hopkinson, N.D., Doherty, M. & Powell, R.J. Clinical features and race-specific incidence/prevalence rates of systemic lupus erythematosus in a geographically complete cohort of patients. Ann. Rheum. Dis. 53, 675–680 (1994).
Wang, J. et al. Systemic lupus erythematosus: a genetic epidemiology study of 695 patients from China. Arch. Dermatol. Res. 298, 485–491 (2007).
Lau, C.S., Yin, G. & Mok, M.Y. Ethnic and geographical differences in systemic lupus erythematosus: an overview. Lupus 15, 715–719 (2006).
Zeng, Q.Y. et al. Rheumatic diseases in China. Arthritis Res. Ther. 10, R17 (2008).
Danchenko, N., Satia, J.A. & Anthony, M.S. Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden. Lupus 15, 308–318 (2006).

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com