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MicroRNA‐146a and Human Disease

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WOS被引频次:135
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成果类型:
期刊论文
作者:
Li, L.;Chen, X.‐P.;Li, Y.‐J.
通讯作者:
Chen, X. -P.
作者机构:
[Chen, X.‐P.; Li, Y.‐J.; Li, L.] Cent S Univ, Dept Pharmacol, Sch Pharmaceut Sci, Changsha 410078, Hunan, Peoples R China.
通讯机构:
[Chen, X. -P.] Cent S Univ, Dept Pharmacol, Sch Pharmaceut Sci, Changsha 410078, Hunan, Peoples R China.
语种:
英文
期刊:
Scandinavian Journal of Immunology
ISSN:
1365-3083
年:
2010
卷:
71
期:
4
页码:
227-231
文献类别:
WOS:Review
所属学科:
ESI学科类别:免疫学;WOS学科类别:Immunology
入藏号:
基金类别:
Chinese National Science Foundation [30671149, 30971584]; China New Century Excellent Talents of Ministry of Education [NCET-07-0859]
机构署名:
本校为第一且通讯机构
院系归属:
湘雅药学院
摘要:
MicroRNAs (MiRNAs) belong to a class of small non‐coding regulatory RNAs that act through repression of protein expression at post‐transcriptional level and emerge to play important roles in many physiological and pathophysiological processes. MiR‐146a is a miRNA supposed to regulate innate immune, inflammatory response and antiviral pathway negatively. In this review, we focus on the recent progress in functional role of miR‐146a in innate immune, inflammatory response, virus infection and human diseases. Together, these findings indicate that manipulation of miR‐146a expression may represent a potential new therapy for several human diseases. Potential use of miR‐146a as a biomarker for disease diagnosis, prevention and treatment is also discussed.
参考文献:
Ambros V, 2004, NATURE, V431, P350, DOI 10.1038/nature02871
Asli NS, 2008, CURR MOL MED, V8, P698, DOI 10.2174/156652408786733739
Bellon M, 2009, BLOOD, V113, P4914, DOI 10.1182/blood-2008-11-189845
Bhaumik D, 2008, ONCOGENE, V27, P5643, DOI 10.1038/onc.2008.171
Boultwood J, 2002, BLOOD, V99, P4638, DOI 10.1182/blood.V99.12.4638

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