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Edoxaban versus Warfarin in Patients with Atrial Fibrillation

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Giugliano, Robert P.;Ruff, Christian T.;Braunwald, Eugene;Murphy, Sabina A.;Wiviott, Stephen D.;Halperin, Jonathan L.;Waldo, Albert L.;Ezekowitz, Michael D.;Weitz, Jeffrey I.;Spinar, Jindrich;Ruzyllo, Witold;Ruda, Mikhail;Koretsune, Yukihiro;Betcher, Joshua;Shi, Minggao;Grip, Laura T.;Patel, Shirali P.;Patel, Indravadan;Hanyok, James J.;Mercuri, Michele;Antman, Elliott M.;Braunwald, E.;Antman, E. M.;Giugliano, R. P.;Ruff, C. T.;Morin, S. E.;Hoffman, E. B.;Murphy, S. A.;Deenadayalu, N.;Grip, L.;Mercuri, M.;Lanz, H.;Patel, I.;Curt, V.;Duggal, A.;Hanyok, J.;Dave, J.;Morgan, D.;Choi, Y.;Shi, M.;Jin, J.;Xie, J.;Crerand, W.;Kappelhof, J.;Maxwell, W.;Skinner, M.;Patel, S.;Betcher, J.;Selicato, G.;Otto, C., Jr.;Reissner, C.;Smith, K.;Ostroske, J.;Ron, A.;Connolly, S.;Camm, J.;Ezekowitz, M.;Halperin, J.;Waldo, A.;Paolasso, E.;Aylward, P.;Heidbuchel, H.;Nicolau, J. C.;Goudev, A.;Roy, D.;Weitz, J.;Corbalan, R.;Yang, Y.;Botero, R.;Bergovec, M.;Spinar, J.;Grande, P.;Hassager, C.;Voitk, J.;Huikuri, H.;Nieminen, M.;Blanc, J. J.;LeHeuzey, J. Y.;Mitrovic, V.;Alexopoulos, D.;Sotomora, G.;Kiss, R.;SomaRaju, B.;Lewis, B.;Merlini, P.;Metra, M.;Koretsune, Y.;Yamashita, T.;Garcia-Castillo, A.;Ophuis, T. Oude;White, H.;Atar, D.;Horna, M.;Babilonia, N.;Ruzyllo, W.;Morais, J.;Dorobantu, M.;Ruda, M.;Ostojic, M.;Duris, T.;Dalby, A.;Chung, N.;Zamorano, J. L.;Juul-Moller, S.;Moccetti, T.;Chen, S. A.;Sritara, P.;Oto, A.;Parkhomenko, A.;Senior, R.;Verheugt, F.;Skene, A.;Anderson, J.;Bauer, K.;Easton, J. D.;Goto, S.;Wiviott, S.;Lowe, C.;Awtry, E.;Berger, C. J.;Croce, K.;Desai, A.;Gelfand, E.;Goessling, W.;Greenberger, N. J.;Ho, C.;Leeman, D. E.;Link, M. S.;Norden, A. D.;Pande, A.;Rost, N.;Ruberg, F.;Silverman, S.;Singhal, A.;Vita, J. A.;Vogelmann, O.;Gonzalez, C.;Guerrero, R. Ahuad;Rodriguez, M.;Albisu, J.;Rosales, E.;Allall, O.;Reguero, M.;Alvarez, C.;Garcia, M.;Ameriso, S.;Ameriso, P.;Amuchastegui, M.;Caceres, M.;Beloscar, J.;Petrucci, J.;Berli, M.;Budassi, N.;Valle, M.;Labarta, G. Bustamante;Saravia, M.;Caccavo, A.;Fracaro, V.;Cartasegna, L.;Novas, V.;Caruso, O.;Zarandon, R. Saa;Colombo, H.;Morandini, M.;Cuello, J.;Rosell, M.;Cuneo, C.;Bocanera, M.;D'Amico, A.;Cendali, G.;Dran, R.;Moreno, V.;Estol, C.;Davolos, M.;Facello, A.;Facello, M.;Falu, E.;Iriarte, M.;Femenia, F.;Arrieta, M.;Fuselli, J.;Zanotti, A.;Lopez, J. Gant;Meiller, F.;Duran, R. Garcia;Perlo, D.;Garrido, M.;Ceirano, C.;Giacomi, G.;Eden, M.;Giannaula, R.;Huerta, M.;Goicoechea, R.;von Wulffen, M.;Hominal, M.;Bianchini, M.;Jure, H.;Jure, D.;Kevorkian, R.;Monaco, F.;Lanternier, G.;Belcuore, M.;Liniado, G.;Iglesias, M.;Litvak, B.;Nigro, A.;Llanos, J.;Vignau, S.;Lorente, C.;Shatsky, K.;Lotti, J.;Raimondi, G.;Mackinnon, I.;Carne, M.;Manuale, O.;Calderon, M.;Marino, J.;Funes, I.;Muntaner, J.;Gandur, H.;Nul, D.;Verdini, E.;Piskorz, D.;Tommasi, A.;Povedano, G.;Casares, E.;Pozzer, D.;Fernandez, E.;Prado, A.;Venturini, C.;Ramos, H.;Navarrete, S.;Alvarez, M.;Sanchez, A.;Bowen, L.;Sanjurjo, M.;Codutti, O.;Toledo, S. Saravia;Formoso, I.;Schmidberg, J.;Goloboulicz, A.;Schygiel, P.;Buzzetti, C.;Severino, P.;Morara, P.;Liprandi, M. Sosa;Teves, M.;Vico, M.;Morell, Y.;Anderson, C.;Paraskevaidis, T.;Arstall, M.;Hoffmann, B.;Colquhoun, D.;Price-Smith, S.;Crimmins, D.;Slattery, A.;Dart, A.;Kay, S.;Davis, S.;Silver, G.;Flecknoe-Brown, S.;Roberts, J.;Gates, P.;Jones, S.;Lehman, R.;Morrison, H.;McKeirnan, M.;Li, J.;Paul, V.;Batta, C.;Purnell, P.;Perrett, L.;Szto, G.;O'Shea, V.;Capiau, L.;Banaeian, F.;De Bleecker, J.;de Koning, K.;De Tollenaere, M.;De Bruyne, L.;Desfontaines, P.;Tincani, G.;Meeusen, K.;Herzet, J.;Malmendier, D.;Mairesse, G.;Raepers, M.;Parque, J.;Scavee, C.;Huyberechts, D.;Stockman, D.;Jacobs, C.;Middelheim, Z. N. A.;Vandekerckhove, Y.;Derycker, K.;Vanwelden, J.;van Welden, J.;Vervoort, G.;Mestdagh, I.;Vrolix, M.;Beerts, C.;Wollaert, B.;Denie, D.;Vincenzo de Paola, A. Amato;Coutinho, E.;Lotufo, P. Andrade;de Melo, R. Ferreira;Atie, J.;Motta, C.;Alves da Costa, F. Augusto;Ferraz, R. Franchin;Bertolim Precoma, D.;Sehnem, E.;Botelho, R.;Cunha, S.;Brondani, R.;Fleck, N.;Chaves Junior, H.;Silva, J.;Costantini, C.;Barroso, D.;De Patta, M.;Pereira, V.;Duda, N.;Laimer, R.;Dutra, O.;Morgado, S.;Faustino Saporito, W.;Seroqui, M.;Ferreira, L.;Araujo, E.;Finimundi, H.;Daitz, C.;Gagliardi, R.;Pereira, G.;Gomes, M.;Gomes, A.;Guimaraes, A.;Ninho, L.;Jaeger, C.;Pereira, L.;Jorge, J.;Cury, C.;Kaiser, S.;Almeida, A.;Kalil, C.;Radaelli, G.;Sebba Barroso de Souza, W. Kunz;Morales, K.;Leaes, P.;Osorio Luiz, R.;Pimenta Almeida, J.;Gozalo, A.;Reis, G.;Avellar, K.;Katz Weiand, L. Reis;Leipelt, J.;Rocha, J.;Barros, R.;Rodrigues, L.;Rubia Rocha, M.;Rodrigues, A.;Rodrigues, D.;Rossi dos Santos, F.;Goncalves Pagnan, L.;Sampaio, R.;do Val, R.;Saraiva, J.;Vicente, C.;Simoes, M.;Carraro, A.;Sobral Filho, D.;Lustosa, E.;Boas, F. Villas;Almeida, M.;Zimmermann, S.;Burger Zimmermann, E.;Chompalova, B.;Parishev, G.;Denchev, S.;Milcheva, N.;Donova, T.;Gergova, V.;Georgiev, B.;Kostova, E.;Kinova, E.;Hergeldjieva, V.;Kamenova, P.;Manolova, A.;Vasilev, I.;Mihov, A.;Miteva, B.;Mincheva, V.;Stoyanovski, V.;Nikolov, F.;Vasilev, D.;Pencheva, G.;Kostov, K.;Petranov, S.;Milusheva, T.;Popov, A.;Staneva, A.;Momchilova-Lozeva, D.;Todorov, G.;Nyagina, M.;Tumbev, H.;Tumbeva, D.;Tzekova, M.;Kitova, M.;Manoylov, E.;Archibald, J.;Antle, S.;Bhargava, R.;Stafford, C.;Hundseth, M.;Cha, J.;Otis, J.;Chehayeb, R.;Lepage, C.;Chilvers, M.;Vansickle, L.;Cleveland, D.;Valley, S.;Constance, C.;Gauthier, M.;Costi, P.;Masson, C.;Coutu, B.;Denis, I.;du Preez, M.;Kubanska, A.;Dufresne, M.;Krider, J.;Eikelboom, J.;Zondag, M.;Fortin, C.;Viau, C.;Green, M.;Houbraken, D.;Hatheway, R.;Mabee, J.;Heath, J.;Scott, L.;Ho, K.;Ho, V.;Hoag, G.;Standring, R.;Huynh, T.;Perkins, L.;Kouz, S.;Roy, M.;Labonte, R.;Dewar, C.;Lainesse, A.;St-Germain, L.;Lam, S.;Lam, H.;Lichtenstein, T.;Roberts, P.;Luton, R.;Douglas, S.;Ma, P.;Seib, M.;MacCallum, C.;Matthews, J.;Malette, P.;Vaillancourt, T.;Maranda, C.;Studenikow, E.;Mawji, A.;Morely, A.;Morrison, D.;Roth, M.;Mucha, M.;Najarali, A.;Lamoureux, U.;Nicholson, R.;O'Hara, G.;Banville, P.;O'Mahony, W.;Bolton, R.;Parkash, R.;Carroll, L.;Pesant, Y.;Sardin, V.;Polasek, P.;Turri, L.;Qureshi, A.;Nethercott, C.;Ricci, J.;Bozek, B.;Rupka, D.;Marchand, C.;Shu, D.;Silverio, G.;St-Hilaire, R.;Morissette, A.;Sussman, J.;Kailey, P.;Syan, G.;Bobbie, C.;Talajic, M.;David, D.;Talbot, P.;Tremblay, M.;Teitelbaum, I.;Teitelbaum, J.;Velthuysen, G.;Giesbrecht, L.;Wahby, R.;Morley, A.;Wharton, S.;Caterini, T.;Woodford, T.;Balboa, W.;Retamal Matus, L.;Bugueno, C.;Mondaca Mondaca, P.;Cobos, J.;Obreque, C.;Parada, A.;Florenzano, F.;Arratia Diaz, P.;Lopetegui, M.;Rebolledo, C.;Manriquez, L.;Manriquez Silva, L.;Martinez, D.;Romero Llamas, R.;Opazo, M.;Carmona Perez, M.;Pincetti, C.;Torres Carrasco, G.;Potthoff, S.;Zapata Staub, J.;Campisto, Y.;Stockins, B.;Lara Lara, C.;Yovaniniz, P.;Grandon Azua, M.;Bai, F.;Xu, G. L.;Chen, J. Z.;Xie, X. D.;Chen, X. P.;Zhang, X.;Dong, Y. G.;Feng, C.;Fu, G. S.;Zhang, P.;Hong, K.;You, Z. G.;Hong, L.;Qiu, Y.;Jiang, X. J.;Qu, Z.;Li, L.;Liu, H.;Li, T. F.;Kong, Y. Q.;Li, W. M.;Liu, B.;Li, Z. Q.;Liu, Y.;Liao, D. N.;Gu, X. J.;Liu, L.;Lu, Z. H.;Ma, S. M.;Yang, Z. Y.;Wang, D. M.;Qi, S. Y.;Wang, G. P.;Shi, X. J.;Wei, M.;Huang, D.;Wu, S. L.;Li, Y. E.;Xu, J. H.;Gu, J. Y.;Xu, Y. M.;Liang, Y. Z.;Yang, K.;Li, A. Y.;Yang, Y. J.;Zheng, X.;Zheng, Y.;Gao, M.;Yin, Y. H.;Xu, Y. P.;Yu, B.;Li, L. L.;Yuan, Z. Y.;Qiang, H.;Zhang, H. Q.;Lin, Y. N.;Zhang, Z.;Kang, H.;Zhao, R. P.;Han, R. J.;Zhao, X. L.;Wang, J. Q.;Zheng, Z. Q.;Li, B. G.;Zhou, S. X.;Zhang, Y. L.;Accini, J.;Accini, M.;Cano, N.;Leon Pineda, L.;Delgado Restrepo, J.;Arroyave, C.;Fernandez Ruiz, R.;Aldana Diaz, I.;Hernandez, H.;Delgado, P.;Jaramillo Munoz, C.;Builes, A.;Manzur, F.;Rivera Rodriguez, E.;Moncada Corredor, M.;Lopez Giraldo, D.;Orozco Linares, L.;Fonseca, J.;Quintero, A.;Gonzales, C.;Sanchez Vallejo, G.;Perdomo Mejia, I.;Bagatin, J.;Carevic, V.;Car, S.;Jeric, M.;Ciglenecki, N.;Tusek, S.;Certic, J. Ferri;Romic, I.;Francetic, I.;Ausperger, K. Makar;Jelic, V.;Jurinjak, S. Jaksic;Knezevic, A.;Buksa, B.;Samardzic, P.;Lukenda, K. Cvitkusic;Steiner, R.;Kirner, D.;Sutalo, K.;Bakliza, Z.;Vrazic, H.;Lucijanic, T.;Bar, M.;Brodova, P.;Berka, L.;Kunkelova, V.;Brtko, M.;Burianova, H.;Cermak, O.;Elbl, L.;Ferkl, R.;Florian, J.;Francek, L.;Golan, L.;Gregor, P.;Honkova, M.;Hubac, J.;Jandik, J.;Jarkovsky, P.;Jelinek, Z.;Jerabek, O.;Jirmar, R.;Kobza, R.;Kochrt, M.;Kostkova, G.;Kosek, Z.;Kovar, P.;Kuchar, R.;Kvasnicka, J.;Ludka, O.;Machova, V.;Krocova, E.;Melichar, M.;Nechanicky, R.;Olsr, J.;Peterka, K.;Petrova, I.;Havlova, I.;Pisova, J.;Podrazil, P.;Jirsova, E.;Reichert, P.;Slaby, J.;Spacek, R.;Labrova, R.;Brno-Bohunice, F. N.;Vodnansky, P.;Samkova, D.;Zidkova, E.;Dodt, K.;Christensen, H.;Loof, A.;Ibsen, H.;Madsen, H.;Iversen, H.;Veng-Olsen, T.;Nielsen, H.;Olsen, R.;Overgaard, K.;Petrovic, V.;Raymond, I.;Raae, D.;Sand, N.;Svenningsen, A.;Wiggers, H.;Serup-Hansen, K.;Kaik, J.;Stern, A.;Kolk, R.;Laane, E.;Rivis, L.;Paumets, M.;Laheaar, M.;Rosenthal, A.;Rajasalu, R.;Vahula, V.;Ratnik, E.;Kaarleenkaski, S.;Hussi, E.;Valpas, S.;Jakala, P.;Lappalainen, T.;Maenpaa, A.;Viitaniemi, J.;Nyman, K.;Sankari, T.;Rasi, H.;Salminen, O.;Virtanen, V.;Nappila, H.;Le Heuzey, J.;Agraou, B.;El Jarroudi, F.;Amarenco, P.;Boursin, P.;Babuty, D.;Boyer, M.;Belhassane, A.;Berbari, H.;Blanc, J.;Dias, P.;Coisne, D.;Berger, N.;Decoulx, E.;El Jarroudi, M.;Dinanian, S.;Arfaoui, M.;Hermida, J.;Deruche, E.;Kacet, S.;Corbut, S.;Poulard, J.;Leparree, S.;Roudaut, R.;Al-Zoebi, A.;Wurow, A.;Bernhardt, P.;Dichristin, U.;Berrouschot, J.;Vierbeck, S.;Beyer-Westendorf, J.;Bouzo, M.;Schnelzer, P.;Braun, R.;Ladenburger, K.;Buhr, M.;Weihrauch, D.;Contzen, C.;Kara, M.;Daut, W.;Ayasse, D.;Degtyareva, E.;Kranz, P.;Drescher, T.;Herfurth, B.;Faghih, M.;ForckBoedeker, K.;Schneider, K.;Fuchs, R.;Manuela, W.;Grigat, C.;Otto, A.;Hartmann, A.;Peitz, M.;Heuer, H.;Dieckheuer, U.;Hoffmann, U.;Dorn, S.;Hoffmann, S.;Schuppe, M.;Horacek, T.;Fink, P.;Junggeburth, J.;Schmid, S.;Jungmair, W.;Schoen, B.;Kleinecke-Pohl, U.;Meusel, P.;Koenig, H.;Bauch, F.;Lohrbaecher-Kozak, I.;Grosse, B.;Lueders, S.;Venneklaas, U.;Luttermann, M.;Wulf, M.;Maus, O.;Hoefer, K.;Meissner, G.;Braemer, U.;Meyer-Pannwitt, U.;Frahm, E.;Vogt, S.;Muegge, A.;Barbera, S.;Mueller-Glamann, M.;Raddatz, K.;Piechatzek, R.;Lewinsky, D.;Pohl, W.;Proskynitopoulos, N.;Rack, K.;Pilipenko, H.;Rinke, A.;Kuhlenborg, A.;Schaefer, A.;Szymanowski, N.;Schellong, S.;Frommhold, R.;Schenkenberger, I.;Finsterbusch, T.;Dreykluft, K.;Schiewe, C.;Schmidt, A.;Schreckenberg, A.;Hellmers, J.;Seibert, H.;Gold, G.;Sohn, H.;Baylacher, M.;Spitzer, S.;Bonin, K.;Stoehring, R.;Taggeselle, J.;Veltkamp, R.;Ludwig, I.;Buchholz, M.;Weyland, K.;Winkelmann, B.;Buelow-Johansen, B.;Wolde, C.;Winter, K.;Mavronasiou, E.;Bourlios, P.;Tziortziotis, A.;Karamitsos, C.;Exarchou, E.;Kifnidis, K.;Daskalaki, A.;Moschos, N.;Dimitra, K.;Olympios, C.;Kartsagkoulis, E.;Pyrgakis, V.;Korantanis, K.;Milla, O. Ayau;Ramirez, V. de Leon;Guzman Melgar, I.;Jimenez, T.;Ovando Lavagnino, A.;Guevara, S.;Rodas Estrada, M.;Sanchez, M.;Mayen Pozuelos, J.;Samayoa, C. Sanchez;Guerra, L.;Velasquez Camas, L.;Padilla Almaraz, S.;Dioszeghy, P.;Muskoczki, E.;Edes, I.;Szatmari, J.;Fiok, J.;Varga, A.;Kanakaridisz, N.;Kosztyu, M.;Kis, E.;Feil, J. Felfoldine;Jakal, A.;Koczka, M.;Kovacs, I.;Baranyai, M.;Kovacs, Z.;Lupkovics, G.;Karakai, H. Horvathne;Matoltsy, A.;Kiss, T.;Medvegy, M.;Kiss, K.;Merkely, B.;Kolumban, E.;Nagy, A.;Palinkas, A.;Toth, S. Rostasne;Sayour, A.;Bognar, A.;Simor, T.;Ruzsa, D.;Sipos, T.;Szakal, I.;Tomcsanyi, J.;Marosi, A.;Vertes, A.;Kincses, M.;Abdullakutty, J.;Agarwal, D.;Ranka, R.;Arneja, J.;Memon, A.;Arora, V.;Shree, R.;Avvaru, G.;Shaikh, A.;Babu, P.;Rao, B.;Babu, R.;Reddy, J.;Banker, D.;Sheth, T.;Benjarge, P.;Surushe, S.;Bharani, A.;Solanki, R.;Bhargava, V.;Biniwale, A.;Bhuti, M.;Calambur, N.;Somaraju, B.;Karnwal, N.;Chopda, M.;Mali, N.;Goyal, N.;Saini, A.;Gupta, J.;Singh, P.;Hadan, S.;Savanth, P.;Hardas, S.;Thakor, G.;Hiremath, J.;Ghume, A.;Jain, R.;Pahuja, M.;Joseph, S.;Oommen, D.;Joseph, J.;Thomas, R.;Joshi, H.;Kale, V.;Raut, N.;Kandekar, B.;Kandekar, S.;Kishore, R.;Krishnan, H.;Kotiwale, V.;Kulkarni, R.;Deokar, M.;Kulkarni, G.;Lawande, A.;Kumar, P.;Karpuram, M.;Kumar, A.;Francis, J.;Kumbla, M.;Anthony, A.;Lavhe, P.;Kale, M.;Mardikar, H.;Bhaskarwar, P.;Mathur, A.;Sharma, P.;Menon, J.;Francis, V.;Namjoshi, D.;Shelke, S.;Narendra, J.;Natarajan, S.;Oomaan, A.;Gurusamy, P.;Angel, J.;Purayil, M. Padinhare;Shams, S.;Pandurangi, U.;Sababathi, R.;Parekh, P.;Jasani, B.;Patki, N.;Babbar, A.;Pinto, B.;Kharalkar, H.;Premchand, R.;Jambula, H.;Rao, M.;Vuriya, A.;Shankar, A. Ravi;Reddy, R.;Bekal, S.;Barai, A.;Saha, D.;Gadepalli, R.;Sant, H.;Jadhav, D.;Sarna, M.;Arora, T.;Sawhney, J.;Singh, R.;Sethi, K.;Bansal, N.;Sethia, A.;Sethia, S.;Shetty, G.;Sudheer, R.;Singh, G.;Gupta, R.;Srinivas, A.;Thankaraj, L.;Varma, S.;Kaur, A.;Vinod, M. Vijan;Thakur, B.;Zanwar, I.;Dharmarao, A.;Atar, S.;Lasri, E.;Dicker, D.;Marcoviciu, D.;Elias, M.;Ron, G. Avraham;Francis, A.;Ghantous, R.;Goldhaber, A.;Goldhaber, M.;Gottlieb, S.;Rouwaida, S.;Grossman, E.;Dagan, T.;Hasin, Y.;Roshrosh, M.;Hayek, T.;Majdoub, A.;Klainman, E.;Genin, I.;Lahav, M.;Gilat, T.;Ben Ari, M.;Lishner, M.;Karny, M.;Ouzan, E.;Givoni, H.;Rozenman, Y.;Logvinenko, S.;Schiff, E.;Sterlin, J.;Shochat, M.;Aloni, I.;Swissa, M.;Belatsky, V.;Tsalihin, D.;Kisos, D.;Zeltser, D.;Platner, N.;Berni, A.;Giovannelli, F.;Boriani, G.;Cervi, E.;Comi, G.;Peruzzotti, L.;Cuccia, C.;Forgione, C.;De Caterina, R.;De Pace, D.;De Servi, S.;Mariani, M.;Di Lenarda, A.;Mazzone, C.;Di Pasquale, G.;Di Niro, M.;Fattore, L.;Bosco, B.;Grassia, V.;Murena, E.;Gaggioli, G.;Lo Pinto, G.;Raggi, F.;Marino, P.;Francalacci, G.;Babbolin, M.;Bulgari, M.;Penco, M.;Lioy, E.;Filardi, P. Perrone;Marciano, C.;Pirelli, S.;Paradiso, G.;Piseddu, G.;Fenu, L.;Raisaro, A.;Granzow, K.;Rasura, M.;Cannoni, S.;Severi, S.;Breschi, M.;Toschi, V.;Gagliano, M.;Zaca, V.;Furiozzi, F.;Hirahara, T.;Akihisa, U.;Masaki, W.;Ajioka, M.;Matsushita, C.;Anzai, T.;Mino, K.;Arakawa, S.;Tsukimine, A.;Endo, H.;Fujiwara, M.;Fujii, K.;Kozeni, S.;Fujii, E.;Kotera, M.;Fujimoto, S.;Omae, K.;Fujimoto, K.;Ichishita, Y.;Fujita, T.;Ito, Y.;Fukamizu, S.;Harada, J.;Fukuda, N.;Fujimoto, C.;Funazaki, T.;Yamaguchi, A.;Furukawa, Y.;Kamitake, C.;Hagiwara, N.;Naganuma, M.;Hara, S.;Kumagai, S.;Harada, K.;Fuki, Y.;Haruna, T.;Nakahara, Y.;Hashimoto, Y.;Shimazu, Y.;Hiasa, Y.;Oga, Y.;Higashikata, T.;Nakagawa, Y.;Hirayama, A.;Kawaguchi, A.;Iesaka, Y.;Miyamoto, C.;Iijima, T.;Higuchi, K.;Ino, H.;Noguchi, H.;Inomata, T.;Nakamura, K.;Ishibashi, Y.;Nozaki, T.;Ishii, Y.;Tomita, H.;Ishimaru, S.;Ise, M.;Itamoto, K.;Ito, T.;Onishi, M.;Iwade, K.;Sakuma, Y.;Iwasaki, T.;Nagatome, H.;Kakinoki, S.;Adachi, C.;Kamakura, S.;Nakahara, F.;Kamijo, M.;Iida, S.;Kamiyama, K.;Fujii, R.;Kato, K.;Ishida, A.;Kazatani, Y.;Ichikawa, Y.;Kitazawa, H.;Igarashi, C.;Kobayashi, Y.;Kikuchi, R.;Kohno, M.;Tamura, S.;Yumoto, I.;Kurabayashi, M.;Koya, E.;Masuyama, T.;Kaneno, Y.;Matsuda, K.;Ebina, E.;Meno, H.;Satake, M.;Mita, T.;Takeda, M.;Miyamoto, N.;Kimizu, T.;Miyauchi, Y.;Sakamoto, S.;Munemasa, M.;Murata, J.;Nagai, Y.;Sakata, Y.;Naito, S.;Oyama, H.;Nishi, Y.;Nagase, T.;Ochiai, J.;Junko, H.;Ogawa, T.;Sugeno, M.;Oguro, H.;Tanabe, M.;Okada, K.;Moriyama, Y.;Okajima, K.;Nakashima, M.;Okazaki, O.;Wada, H.;Okishige, K.;Kitani, S.;Okumura, K.;Narita, Y.;Onaka, H.;Moriyama, H.;Ozaki, Y.;Tanikawa, I.;Sakagami, S.;Nakano, A.;Sakuragi, S.;Hayashi, N.;Sakurai, S.;Ooki, H.;Sasaki, T.;Oosawa, N.;Satoh, A.;Fujimoto, E.;Seino, Y.;Narumi, M.;Shirai, T.;Shigenari, M.;Shoji, Y.;Ueda, J.;Sugi, K.;Sumii, K.;Asakura, H.;Takagi, M.;Mohri, S.;Takahashi, W.;Yoshida, K.;Takahashi, A.;Kishi, N.;Takahashi, T.;Sakurai, Y.;Takeda, K.;Yahata, A.;Takenaka, T.;Yamagishi, K.;Takeuchi, S.;Watanabe, E.;Tanaka, K.;Uchida, M.;Tanouchi, J.;Nishiya, Y.;Tsuboi, H.;Tsuboi, N.;Terakura, K.;Uematsu, M.;Yasumoto, S.;Ueyama, Y.;Usuda, K.;Sakai, Y.;Yagi, M.;Sato, A.;Yagi, H.;Kuroda, T.;Yamabe, H.;Sakamoto, Y.;Yamada, T.;Yamano, R.;Yamagishi, T.;Sasaki, S.;Yamamoto, Y.;Yamashina, A.;Takiguchi, M.;Yonehara, T.;Yoshino, H.;Nomura, H.;Yoshioka, K.;Fujiwara, Y.;Llamas, E. Bayram;Hurtado, A.;Vargas, C. Calvo;Limon, M. Cedano;Munoz, E. Cardona;Hernandez, S.;Carrillo, J.;Delgadillo, T.;Ramirez, M. Casares;Valles, J. Franco;Garcia, N.;Colin, M. Alcantara;Jaramillo, A.;Leiva-Pons, J.;de la Mora, S.;Esperon, G. Llamas;Grajales, A.;Mendez-Machado, G.;Avila, H.;Ruiz, L. Nevarez;Magallanes, G.;Diaz, C. Sanchez;Ortiz, A.;Sanchez, R. Velasco;Velazquez, E. Moran;Alhakim, M.;van Welsen, I.;Bruning, T.;Jones, A.;Buiks, C.;de Groot, J.;Radder, I.;de Vos, R.;Hazeleger, R.;Daniels, R.;Kietselaer, B.;Muijs, L.;Mannaerts, H.;Kooiman, E.;Mevissen, H.;van der Heijden, D.;Hofmeyer, H.;Anscombe, R.;O'Meeghan, T.;Kjentjes, M.;Benatar, J.;Borthwick, L.;Doughty, R.;Copley, M.;Fisher, R.;Monkley, R.;Green, B.;Scott, D.;Hamer, A.;Tomlinson, J.;Hart, H.;Turner, A.;Cammell, R.;Troughton, R.;Skelton, L.;Young, C.;Kennett, K.;Claussen, H.;Hofsoy, K.;Melbue, R.;Sandvik, J.;Thunhaug, H.;Tveit, A.;Enger, S.;Bustamante, G.;Guillen, M. Tejada;Cabrera, J.;Mendoza, R. Esteves;Chavez, C.;Luna, C.;Lema, J.;Carrion, A.;Llerena, N.;Bedregal, S. Araoz;Palomino, F. Medina;Rodriguez, J.;Minchola, J.;Bautista, C.;Miguel, S. Negron;Armas, B. Honores;Rodriguez, A.;Romero, N.;Torres, P.;Rodriguez, K. Fernandez;Chavez, P. Yanac;Delgado, S.;Sambaz, C. M.;Barcinas, R.;Zapanta, M.;Coching, R.;Vallenas, M.;Matiga, G.;Enad, C.;Rogelio, G.;Joaquin, F.;Roxas, A., Jr.;Gilo, L.;To, R.;Aquino, M.;Villamor, L.;Nario, K.;Adamus, J.;Korzeniowska-Adamus, J.;Baszak, J.;Bronisz, M.;Busz-Papiez, B.;Krzystolik, A.;Cymerman, K.;Dabrowska, M.;Ptak, A.;Derlaga, B.;Laskowska-Derlaga, E.;Domanska, E.;Guziewicz, M.;Gieroba, A.;Zajac, E.;Gniot, J.;Mroczkowski, P.;Januszewicz, A.;Makowiecka-Ciesla, M.;Jazwinska-Tarnawska, E.;Ciezak, P.;Jurowiecki, J.;Kaczmarek, B.;Pacholska, A.;Kaminski, L.;Kania, G.;Tymendorf, K.;Karczmarczyk, A.;Kaliszczak, R.;Konieczny, M.;Benicka, E.;Korzeniak, R.;Borowski, W.;Krzyzanowski, W.;Muzyk-Osikowicz, M.;Kus, W.;Lesnik, J.;Wierzykowski, T.;Lewczuk, J.;Stopyra-Poczatek, M.;Lubinski, A.;Szymanska, K.;Lysek, R.;Jaguszewska, G.;Matyszczak-Toniak, L.;Sznajder, R.;Wnetrzak-Michalska, R.;Kosmaczewska, A.;Mazur, S.;Chmielowski, A.;Miekus, P.;Kosmalska, K.;Mosiewicz, J.;Myslinski, W. .;Napora, P.;Biniek, D.;Nessler, J.;Nessler, B.;Niezgoda, K.;Nej, A.;Nowak, J.;Olszewski, M.;Podjacka, D.;Janczewska, D.;Pogorzelska, H.;Polaszewska-Pulkownik, V.;Bojanowska, E.;Raczak, G.;Zienciuk-Krajka, A.;Rewinska, H.;Rozmyslowicz-Szerminska, W.;Ronkowski, R.;Norwa-Otto, B.;Sendrowski, D.;Spyra, J.;Szolkiewicz, M.;Malanska, A.;Turbak, R.;Wrobel, W.;Muzalewski, P.;Wysokinski, A.;Kudlicki, J.;Zarebinski, M.;Krauze, R.;Zielinski, M.;Nawrot, M.;Matias, F.;Correia, J.;Gil, V.;Lopes, S.;Madeira, J.;Maymone, D.;Martins, D.;Neves, E.;Monteiro, P.;Oliveira, D.;Marques, A. Leitao;Castro, C.;Salgado, A.;Goncalves, A.;Marcos, H. Sao;Santos, O.;Pais Nunes, L. Veiga;Teotonio, H. Sao;Santos, J.;Soares, D.;Albulescu, P.;Ciortea, M.;Apetrei, E.;Matei, C.;Bartos, D.;Badila, E.;Bengus, C.;Ochean, V.;Bobescu, E.;Doka, B.;Bolohan, F.;Ciobotaru, G.;Andor, M.;Coman, I.;Ghionea, M.;Constantinescu, M.;Creteanu, M.;Parasteac, M.;Cristea, M.;Anciu, M.;Crisu, D.;Jemna, D.;Dobre, I.;Voicu, O.;Dobreanu, D.;Sirbu, I.;Dragomir, D.;Jurca, S.;Iosipescu, L.;Costache, L.;Minescu, B.;Serban, D.;Pop, C.;Cozma, M.;Popescu, M.;Ardelean, A.;Sipciu, D.;Plosca, P.;Stamate, S.;Spinu, C.;Topolnitchi, L.;Tudoran, M.;Tudoran, C.;Zhukova, N.;Arutyunov, G.;Chernyavskaya, T.;Ballyuzek, M.;Alexandrova, L.;Barbarash, O.;Bashkireva, A.;Bart, B.;Larina, V.;Belenky, D.;Kosolapov, Y.;Berns, S.;Yukhno, E.;Bokarev, I.;Khlevchuk, T.;Chumakova, G.;Pokutneva, O.;Demko, A.;Masin, A.;Dovgalevsky, P.;Puchinyan, N.;Drapkina, O.;Zyatenkova, E.;Egorova, L.;Esip, V.;Kirichek, N.;Filatov, A.;Soin, I.;Gilinskaya, O.;Valuyshkih, E.;Glezer, M.;Valovyeva, S.;Golitsyn, S.;Kratskina, T.;Goloshchekin, B.;Laptev, I.;Gratsiansky, N.;Mazovets, O.;Karpov, Y.;Buza, V.;Kosenko, B.;Khirmanov, V.;Kireenkov, I.;Khokhlov, A.;Sinitsina, O.;Khokhlov, R.;Tsareva, E.;Khrustalev, O.;Khrustalev, A.;Kostenko, V.;Karabalieva, S.;Koziolova, N.;Polyanskaya, E.;Kozyrev, O.;Kostenko, O.;Kuznetsov, V.;Rychkov, A.;Lavrova, O.;Tereschenko, L.;Levashov, S.;Volkova, E.;Libis, R.;Maslova, A.;Libov, I.;Moiseeva, Y.;Lila, A.;Belousova, L.;Lukyanov, Y.;Lamden, D.;Nikolaev, K.;Nikolskaya, I.;Khromova, O.;Novikova, N.;Patrusheva, S.;Panchenko, E.;Laguta, P.;Panov, A.;Nilk, R.;Polkanova, E.;Matveeva, I.;Poluyanova, N.;Pikalova, N.;Raskina, T.;Letaeva, M.;Rebrov, A.;Karoli, N.;Repin, M.;Rodina, N.;Shaposhnik, I.;Lebedev, E.;Shogenov, Z.;Agirov, M.;Sidorenko, B.;Vorontsova, S.;Sinitsina, I.;Orlov, V.;Golshmid, M.;Sizova, Z.;Lapidus, N.;Sobolev, K.;Erofeeva, S.;Suprun, E.;Dronov, D.;Tarasov, N.;Isakov, L.;Tereshenko, S.;Kositsyna, I.;Tikhonova, E.;Solovyev, A.;Timofeev, A.;Bulygin, S.;Ustyugov, S.;Rossovskaya, M.;Vishnevsky, A.;Kirgizova, A.;Volkov, D.;Yakusevich, V.;Petrochenko, A.;Yakushin, S.;Nikulina, N.;Zateyshchikov, D.;Zotova, I.;Zateyshchikova, A.;Mankhaeva, B.;Zenin, S.;Kononenko, O.;Zubeeva, G.;Motylev, I.;Apostolovic, S.;Djordjevic-Radojkovic, D.;Celic, V.;Majstorovic, A.;Adjic, N. Cemerlic;Bjelobrk, M.;Despotovic, N.;Erceg, P.;Ilic, S.;Ilic, B.;Krotin, M.;Djokovic, A.;Miloradovic, V.;Djokic, I.;Otasevic, P.;Tasic, N.;Potpara, T.;Polovina, M.;Putnikovic, B.;Kalezic, T.;Seferovic, P.;Milinkovic, I.;Tavciovski, D.;Davicevic, Z.;Vasiljevic-Pokrajcic, Z.;Mitrovic, P.;Tesic, B. Vujisic;Tesic, M.;Ambrovicova, V.;Ambrovic, I.;Banikova, A.;Dukat, A.;Kosmalova, V.;Dulkova, K.;Dulka, T.;Dzupina, A.;Dzupinova, M.;Hatalova, K.;Hatala, R.;Hranai, M.;Hofmanova, J.;Kasperova, V.;Reptova, A.;Mazur, J.;Pella, D.;Fedacko, J.;Ruffini, L.;Morsky, J.;Slanina, M.;Kmec, J.;Zachar, A.;Kokles, M.;Zareczky, P.;Bollova, D.;Badenhorst, J.;Erasmus, L.;Basson, M.;Poynton, M.;Allman, J.;Ellis, G.;Botha, L.;Engelbrecht, J.;Mostert, M.;Essop, M.;Nunkoo, T.;Gani, M.;Wilson, L.;Kelfkens, Y.;Mitha, I.;Taljaard, J.;Naidoo, D.;Duki, Y.;Snyders, F.;Munnik, M.;Soma, P.;Johnston, H.;van der Merwe, N.;Goosen, Y.;van Zyl, L.;le Roux, M.;Venter, T.;Wessels, L.;Bae, H. J.;Han, M. G.;Cha, J. K.;Kim, D. H.;Cho, B. R.;Ryu, D. R.;Choi, H. H.;Hong, K. S.;Chung, W. S.;Oh, Y. S.;Han, S. H.;Lee, K. H.;Hong, T. J.;Lee, H. W.;Hyon, M. S.;Jung, J. W.;Jeon, H. K.;Lee, J. M.;Kang, D. H.;Choi, K. J.;Kim, C. J.;Jin, E. S.;Kim, D. S.;Seo, J. S.;Kim, H. S.;Cha, M. J.;Kim, J. T.;Park, M. S.;Kim, J. H.;Park, J. H.;Kim, J. S.;Park, S. J.;Kim, S. H.;Seo, J. B.;Kim, Y. J.;Chun, M. Y.;Lee, M. H.;Joung, B. Y.;Lee, S. H.;Shin, D. G.;Namgung, J.;Kwak, J. J.;Rha, S. W.;Na, J. O.;Rim, S. J.;Kim, J. Y.;Arcocha Torres, M.;Manzanal Rey, A.;Blanco Coronado, J.;Puertas, I.;Bruguera Cortada, J.;Cabero, P.;del Mar, H.;Calvo, C.;Calvo, G.;de Arce Borda, A.;Asensio, A.;Diez Tejedor, E.;Perez Guevara, M.;Gonzalez Juanatey, J.;Moure, M.;Delgado, A.;Lopez Garcia-Aranda, V.;Barquero, R.;Manzano, L.;Blanco Abril, S.;Diaz-Pintado, M.;Merino, J.;Arias, J.;Fernandez, M.;Fernandez Alvarez, R.;Terns, M.;Dachs Delgado, M.;Villuendas, R.;Astier, L.;Appelros, P.;Akerberg, A.;Blom, K. Berndtsson;Andersson, R.;Blomstrom, P.;Persson, L.;Carlsson, T.;Bengtsson, A. Stener;Dettmann, S.;Ostberg, S.;Engdahl, J.;Karlsson, L.;Herlitz, J.;Winberg, L.;Jernhed, H.;Koskinen, P.;Hakansson, E.;Kozak, P.;Edlund, M.;Malmqvist, L.;Eriksson, G.;Randers, F.;Moodh, J.;Rautio, A.;Johansson, M.;Ronn, F.;Sundholm, C.;Stenberg, A.;Gunnarsson, A.;Thulin, J.;Broberg, M.;Slater, I. Petrova;Cheng, C. C.;Wu, W. S.;Chiang, C. E.;Yu, W. C.;Chiang, F. T.;Wu, Y. W.;Chiou, C. W.;Yeh, T. C.;Hsia, C. H.;Chen, Y. P.;Huang, J. L.;Chen, Y. F.;Kuo, C. T.;Wang, C. L.;Lai, W. T.;Lin, T. H.;Lee, J. T.;Pai, P. Y.;Lin, K. H.;Shyu, K. G.;Chiu, C. Z.;Tseng, W. K.;Pan, Y. F.;Ueng, K. C.;Lee, S. C.;Wang, J. H.;Tsai, W. C.;Yeh, H. I.;Kuo, J. Y.;Jirasirirojanakorn, K.;Pornchaiyasit, K.;Kaewsuwanna, P.;Sinthusopa, W.;Kiatchoosakun, S.;Sriprasert, S.;Laothavorn, P.;Bamrungpong, P.;Piyayotai, D.;Sripracha, A.;Panpunuan, P.;Sukonthasarn, A.;Mekara, W.;Vorasettakarnkij, Y.;Puripun, E.;Acikel, M.;Akilli, H.;Demir, H.;Ata, N.;Bayata, S.;Cakmak, N.;Calik, A.;Cayli, M.;Ceyhan, C.;Erdogan, D.;Ermis, C.;Kabul, K.;Kanadasi, M.;Turgut, O.;Tandogan, I.;Yalcin, R.;Yigit, F.;Yigit, Z.;Zoghi, M.;Batushkin, V.;Azhdari, M.;Bazylevych, A.;Vlasyuk, Z.;Bereznyakov, I.;Lebedynskaya, M.;Dotsenko, S.;Kulynych, R.;Dzyak, G.;Vasilyeva, L.;Faynyk, A.;Sorokivskyy, M.;Gavrysyuk, V.;Dzublik, Y.;Horbach, L.;Husyev, V.;Godlevska, O.;Samburg, Y.;Karpenko, O.;Nevolina, I.;Karpenko, Y.;Blihar, O.;Kaydashev, I.;Gerasimenko, N.;Kolomyyits, S.;Vasylets, V.;Kopytsya, M.;Petyunina, O.;Kotseruba, V.;Dvoieglazova, M.;Koval, V.;Ohirko, O.;Koval, O.;Kaplan, P.;Kraiz, I.;Usan, N.;Kraydashenko, O.;Stets, R.;Kupnovytska, I.;Kyyak, Y.;Lizogub, V.;Gorna, O.;Malynovsky, Y.;Fedotov, S.;Ostrovska, L.;Ushakova-Sokolova, L.;Dovgan, N.;Potapenko, P.;Nekrasa, A.;Prokhorov, O.;Leonidova, V.;Rebrov, B.;Gamachek, O.;Rishko, M.;Chendey, T.;Rudyk, I.;Shatilo, V.;Ishchuk, V.;Shcherbak, V.;Goncharova, I.;Shvetz, N.;Zamlynskyy, M.;Sirenko, Y.;Stanislavchuk, M.;Perebetiuk, L.;Sychov, O.;Lyzohub, S.;Tseluyko, V.;Kuznetsov, I.;Tykhonova, S.;Vakaliuk, I.;Drapchak, I.;Vatutin, M.;Sklyanna, O.;Vizir, V.;Goncharov, O.;Volkov, V.;Serik, S.;Yagensky, A.;Nahrebetskyy, V.;Yena, L.;Mudruk, I.;Zharinov, O.;Logvinov, Y.;Zhurba, S.;Shandra, T.;Aggarwal, R.;Smith, S.;Beeton, I.;Dunn, S.;Blagden, M.;Price, R.;Dougal, K.;Chapman, O.;Davies, D.;Choy, A.;Duff, J.;Cohen, A.;Wilmott, R.;D'Costa, D.;Douglas, H.;Dickinson, D.;Lie, F.;Ramasamy, V.;Lindsay, S.;Atkinson, C.;Linker, N.;Finlayson, M.;Lip, G.;Brown, R.;MacCallum, P.;Ebano, P.;MacLeod, M.;McGhee, C.;Marazzi, P.;Jones, D.;Maxwell, T.;Isted, C.;More, R.;Helliwell, L.;Moriarty, A.;Mackin, A.;Murdoch, D.;Andrews, A.;Newby, D.;Flint, L.;Pye, M.;Wright, L.;Avery, D.;Young, G.;Sopher, M.;Kennard, S.;Storey, R.;Bridge, C.;Turner, W.;Walker, M.;Venkataraman, A.;Gilchrist, M.;Watkin, R.;Chung, A.;Wright, A.;Wright, J.;Panella, M.;Adams, K.;Lohman, J.;Adler, J.;Barash, B.;Adler, P.;Reiling, S.;Beck, P.;Ahmad, A.;Hussain, A.;Ahmadpour, H.;Lim, G.;Akhter, F.;Brubaker, S.;Alexander, J.;Genova-Peeva, E.;Aliyar, P.;Godsey, W.;Allison, J.;Biscardi, R.;Almquist, A.;MacDonald, H.;Alsheikh, T.;Lane, B.;Amin, K.;Khetarpal, S.;Amin, M.;Persechino, F.;York, T.;Arnold, T.;Shoaf, R.;Arouni, A.;Rasmussen, L.;Attanti, S.;Strickland, S.;Aude, Y.;Cobos, D.;Awasty, V.;Baldwin, E.;Ayesu, K.;Thompson, B.;Baine, S.;Batista, M.;Baman, R.;Campbell, G.;Barber, M.;Altonen, D.;Barker, T.;Faircloth, C.;Barrington, P.;Gordon, L.;Bartkowiak, A.;Benton, J.;Beasley, R.;Hoffman, T.;Bedoya, R.;Luis-Valdes, M.;Bedwell, N.;Craig, M.;Beinart, S.;Swaim, D.;Bensimhon, D.;Garman, V.;Berk, M.;Ibarra, M.;Bernard, J.;Eldred, R.;Bernard, John V.;Bilal, B.;Preston, S.;Bilazarian, S.;Langone, L.;Bingham, S.;Antonino, M.;Block, T.;Talbot-, Lawson C.;Blonder, R.;Ensminger, E.;Bloomberg, R.;Bloomberg, K.;Blue, B.;Vernon, M.;Borsheim, M.;Hickenbotham, D.;Bouchard, A.;Wade, W.;Bowden, W.;Ziegler, K.;Bradley, A.;Terry, P.;Brilakis, E.;Frey, W.;Brown, H.;Triano, A.;Bybee, K.;Al-Maliky, T.;Cader, C.;Morton, S.;Canaday, D.;Canosa, R.;Hartranft, E.;Caplan, J.;Jameson, L.;Carr, K.;Phan, D.;Chang, M.;Hatfield, G.;Charlat, M.;Tamayo, M.;Chaturvedi, S.;Sawaya, K.;Ciaramita, J.;Bagby, J.;Clapp, T.;Clay, A.;McClelland, M.;Dutka, C.;Cohen, R.;Bossaers, J.;Colan, D.;Salpas, S.;Cole, J.;Fisher, M.;Concha, M.;Martinez, E.;Corbett, B.;Svadbik, L.;Cossu, S.;Mullinax, K.;Cottiero, R.;Masson, E.;Cowan, L.;Nelson, L.;Curtis, B.;Sarpola, N.;Dang, N.;Morgan, T.;Daniels, S.;Leka, G.;Datta, S.;Wulf, A.;Dave, K.;Dave, B.;Davuluri, A.;Ebreo, N.;De Lemos, J.;Debes, C.;Dean, J.;Warmack, D.;DeGarmo, R.;Carey, J.;Steward, A.;Desire, A.;Waters, L.;Devenport, S.;Briscoe, C.;Dhar, S.;Ucik, S.;DiGiovanna, M.;Tisdale, L.;Donovan, D.;Rodriguez, L.;Dotani, I.;Olson, A.;Drozdiak, R.;Habibi, S.;D'Souza, A.;Cullen, T.;Eade, J.;Dunn, K.;Eldadah, Z.;Quick, R.;Ellis, J.;Cristaldi, J.;Bridgewater, E.;Erenrich, N.;Johnson, C.;O'Brien, J.;Ettinger, N.;Shipp, A.;Everhart, B.;DeSalle, D.;Fahmy, R.;Watkins, D.;Feld, L.;Tameron, A.;Feldman, J.;Tang, N.;Felten, W.;Prior, J.;Fialkow, J.;Calvo, M.;Finkel, M.;Shriver, D.;Finkelstein, S.;Fischell, T.;Drew, B.;Fishbein, G.;Donahue, S.;Flores, E.;Slayton, C.;Forman, S.;Solis, A.;Frais, M.;Thrope, C.;Franco, M.;Gentry, P.;French, W.;Morales, C.;Friedlander, I.;Gaffney, M.;Jones, J.;Garb, J.;Miranda, J.;George, F.;Valentine, H.;Gerber, J.;Hinchion, N.;Gillespie, E.;Keane-Richmond, P.;Gogia, H.;Ewing, B.;Goldscher, D.;Latteri, J.;Goldstein, M.;Gowda, S.;Rafala, E.;Graham, S.;Bonora, M.;Griffin, S.;Aull, L.;Griffin, J.;Goodman, V.;Grossman, C.;Davis, A.;Grove, D.;Mabe, K.;Guarino, J.;Gabela, W.;Guarnieri, T.;Foster, B.;Guthrie, R.;Felsman, D.;Gvora, T.;McLean, R.;Hack, T.;Morelli, L.;Hamroff, G.;Bentivenga, L.;Han, M.;Cavanna, L.;Harris, J.;Bobade, M.;Hearne, S.;Krater, C.;Heiman, M.;Dandekar, U.;Shah, D.;Henderson, D.;Millard, D.;Henry, S.;Harkins, V.;Hermany, P.;Batchell, K.;Herrod, J.;Miranda, D.;Herson, S.;Carey, G.;Hinchman, D.;Vieira, P.;Hippert, R.;Dutter, S.;Hoekstra, J.;Homan, J.;Homayouni, A.;Horton, K.;Sloss, D.;Hotchkiss, D.;Turner, N.;Houchin, V.;Howard, V.;Hays, D.;Howard, L.;Craft, D.;Huang, P.;Truva, C.;Hunter, J.;Battistelli, E.;Hurst, P.;Garza, M.;Hussain, M.;Tambawala, M.;Ison, R.;Butcher, S.;Jardula, M.;Andresen, T.;Johnson, F.;Phillips, T.;Jones, R.;Hughett, G.;Jovin, I.;Nichols, M.;Judson, P.;Royes, A.;Kahn, B.;Coombs, V.;Kai, W.;Dugal, J.;Kandath, D.;Kostedt, G.;Kaplan, K.;Cook, S.;Kapoor, A.;Ruggiero, M.;Karunaratne, H.;Behm, K.;Kastelic, R.;Davis, C.;Keller, R.;Keller, J.;Kerkering, M.;Bartholomaus, D.;Kersh, R.;Buhler, A.;Kesselbrenner, M.;DiCorcia, L.;Khan, B.;Binns, M.;Khan, M.;Khan, G.;Kindman, L.;Averett, P.;Korpas, D.;Godfrey, C.;Kotha, P.;Kozlowski, J.;Watts, S.;Krichmar, P.;Marquez, D.;Laliotis, A.;Jauregui, V.;Lambert, C.;Coyle, Stagi G.;Landau, C.;Ferguson, D.;Lang, J.;Simmons, T.;Langevin, E.;Faucett, S.;Ledbetter, L.;Royse, H.;Lentz, M.;Smith, D.;Lesser, M.;Hartley, L.;Lewis, D.;Bonds, C.;Lillestol, M.;Miller, D.;Ling, L.;Murphy, R.;Littlefield, R.;Wofford, E.;Lomnitz, D.;Lone, B.;Davids, M.;Looby, R.;Ault, S.;Lui, H.;Wright, H.;Lurie, M.;Edelstein, J.;Macomber, J.;Bush, D.;Magee, A.;Doctor, A.;Mainigi, S.;Lisiecki, B.;Makam, S.;Casas, R.;Mandviwala, M.;Marar, I.;Rabadi-Marar, D.;Marenberg, M.;Bedenko, E.;Massin, E.;Hicks, T.;McCartney, M.;Stubbs, L.;McGarvey, J.;Schwarz, L.;McGuire, K.;McKenzie, M.;Rodkey, K.;McKnight, T.;Paul, J.;McLaurin, B.;Lack, A.;Mega, J.;Marti, J.;Meholick, A.;Skinner, J.;Mehrle, A.;Wall, J.;Mendelson, R.;Cervellione, K.;Mercado, A.;Cajulis, C.;Michlin, B.;Romero-Colon, J.;Milas, J.;Sanders, D.;Miller, R.;Sanchez, S.;Miller, S.;Gryczan, J.;Mody, F.;Strugatsky, S.;Moran, J.;Garner, S.;Morledge, J.;Bowman, B.;Mouhaffel, A.;Parrott, N.;Mounsey, P.;Schuler, C.;Mowdy, M.;Todd, S.;Mullen, P.;Raziano, S.;Murphy, A.;Oehmann, V.;Nadar, V.;Parker, A.;Naidu, J.;West, M.;Nallasivan, M.;Goza, J.;Nguyen, T.;Nomanee, S.;Nielsen, R.;Wilmot, M.;Oberoi, M.;Thakkar, N.;Oppenheimer, K.;McCormick, J.;Orchard, R.;Garcia, L.;Osborne, J.;Gonzalez, M.;Oza, S.;Joseph, L.;Patnam, S.;Dennison, K.;Pavon, H.;Gorry, N.;Pearlstein, R.;Pentz, W.;Duncan, D.;Peters, P.;Chacon, L.;Petruzziello, F.;Morlando, F.;Pettis, K.;Brown, F.;Pezzella, S.;Kirk, D.;Poulathas, A.;Cush, S.;Pratt, R.;Neeper, L.;Pribble, A.;Lowe, K.;Pudi, K.;Sham, L.;Pugeda, J.;Ebert, J.;Quadrel, M.;Rafla, E.;Quinlan, E.;Reed, C.;Quinn, J.;Hemmen, C.;Rama, P.;Domingo, D.;Redondo, V.;Wroblewski, J.;Renzi, M.;Stanley, E.;Richwine, R.;Pazier, P.;Riofrio, K.;Braun, D.;Robinson, J.;Cherrico, M.;Roehll, W.;Hollihan, P.;Barnhorst, M.;Rosado, J.;Bamhorst, M.;Rosen, R.;Martin, C.;Ross, S.;Freeman, R.;Ruoff, G.;Nelson, T.;Sacco, J.;Ball, E.;Samal, A.;Schomburg, J.;Sandberg, J.;Lafave, J.;Savin, V.;Clifton, R.;Schaefer, S.;Fekete, A.;Schneider, R.;Schneider, W.;Schulman, D.;Mercer, S.;Seals, A.;Ullig, T.;Holt, A.;Seide, H.;Mather, N.;Shah, G.;Witt, P.;Shalaby, A.;Seese, M.;Shanes, J.;Fleets, J.;Shaoulian, E.;Hren, A.;Sheikh, K.;Hengerer, T.;Shih, H.;Browning, J.;Shoukfeh, M.;Stephenson, L.;Siler, T.;Champagne, M.;Simpson, P.;Meyer, R.;Singh, N.;Turner, K.;Singh, V.;Nelson, M.;Skierka, R.;Hughes, B.;Keene, R.;Smith, R.;Hodnett, P.;Spangenthal, S.;Thomason, L.;Sperling, M.;Vasquez, E.;Spivack, E.;McCartney, P.;Staniloae, C.;Liu, M.;Steljes, A.;Cox, C.;Struble, R.;Vittitow, T.;Suresh, D.;Frost, J.;Swerchowsky, V.;Freemyer, D.;Szulawski, I.;Herwehe, S.;Tahirkheli, N.;Springer, K.;Takata, T.;Bruton, T.;Talano, J.;Leo, L.;Tami, L.;Corchado, D.;Tatarko, M.;Swauger, M.;Tawney, K.;Dastoli, K.;Teague, S.;Young, K.;Tee, H.;Mitchell, T.;Teixeira, J.;Southam, D.;Torres, 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Gonzalez;Vemireddy, D.;Cardoza, T.;Verma, S.;Parsons, T.;Vicari, R.;Warren, K.;Vijay, N.;Washam, M.;Vossler, M.;Kilcup, S.;Walsh, R.;Renaud, K.;Ward, S.;Locklear, T.;Waxman, F.;Sanchez, G.;Weiss, R.;St Laurent, B.;Westcott, J.;Williams, D.;Gibson, C.;Williams, R.;C, Dowling;Willis, J.;VonGerichten, S.;Wood, K.;Capasso-Gulve, E.;Worley, S.;Pointer, S.;Yarows, S.;Sheehan, T.;Yasin, M.;Yi, J.;Dongas, B.;Yousuf, K.;Zakhary, B.;Curtis, S.;Zeig, S.;Mason, T.;Zellner, C.;Harden, M.;Roper, E.;Waseem, M.;Grammer, M.;Clinckemaille, N.;Bose, S.;Torp-Pedersen, C.;Jakobsen, U.;Duprat, C.
通讯作者:
Giugliano, RP
作者机构:
[Morrison, H.; Lehman, R.] Adelaide Med Res, Ashford, SA, Australia.
[Iriarte, M.; Falu, E.] Sanatorio Carmen, Salta, Argentina.
[Giesbrecht, L.; Velthuysen, G.] Holley Clin, Quebec City, PQ, Canada.
[Kacet, S.; Corbut, S.] Hosp Cardiol Chru Lille, Lille, France.
[Lappalainen, T.; Jakala, P.] Ita Suomen Yliopisto Kuopion Kampus, Kliininen Tutkimuskesk, Kuopio, Finland.
通讯机构:
[Giugliano, RP] Brigham & Womens Hosp, Div Cardiovasc Med, TIMI Study Grp, 350 Longwood Ave,1st Flr, Boston, MA 02115 USA.
语种:
英文
期刊:
NEW ENGLAND JOURNAL OF MEDICINE
ISSN:
0028-4793
年:
2013
卷:
369
期:
22
页码:
2093-2104
文献类别:
WOS:Article
所属学科:
ESI学科类别:临床医学;WOS学科类别:Medicine, General & Internal
入藏号:
基金类别:
Daiichi Sankyo Pharma Development; Daiichi Sankyo; Janssen Pharmaceuticals; Merck; Bristol-Myers Squibb; Sanofi; Johnson Johnson; AstraZeneca; Boehringer Ingelheim; Genzyme; Amorcyte; Medicines Company; Cardiorentis; Eli Lilly; Menarini; Medscape; Bayer HealthCare; GlaxoSmithKline; Beckman Coulter; Roche Diagnostics; Pfizer; Eisai; Arena Pharmaceuticals; Aegerion; AngelMed; Xoma; ICON Clinical Research; Boston Clinical Research Institute; Ortho-McNeil-Janssen Pharmaceuticals; Biotronik; Boston Scientific; Medtronic; Cardio-Insight; ChanRx; Portola Pharmaceuticals; Janssen Scientific Affairs; Pozen; Coherex Medical; Gilead
机构署名:
本校为其他机构
院系归属:
基础医学院
湘雅医院(第一临床学院)
湘雅二医院(第二临床学院)
湘雅三医院(第三临床学院)
摘要:
BackgroundEdoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. MethodsWe conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. ResultsThe annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). ConclusionsBoth once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)
参考文献:
Buller HR, 2013, NEW ENGL J MED, V369, P1406, DOI 10.1056/NEJMoa1306638
Connolly SJ, 2009, NEW ENGL J MED, V361, P1139, DOI 10.1056/NEJMoa0905561
Dogliotti A, 2013, CLIN CARDIOL, V36, P61, DOI 10.1002/clc.22081
Food and Drug Administration, 2010, GUIDANCE FOR INDUSTR
Fukuda T, 2012, THROMB HAEMOSTASIS, V107, P253, DOI 10.1160/TH11-09-0668

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