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Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation

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WOS被引频次:220
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成果类型:
期刊论文
作者:
Guo, Guangwu;Sun, Xiaojuan;Chen, Chao;Wu, Song;Huang, Peide;Li, Zesong;Dean, Michael;Huang, Yi;Jia, Wenlong;Zhou, Quan;Tang, Aifa;Yang, Zuoquan;Li, Xianxin;Song, Pengfei;Zhao, Xiaokun;Ye, Rui;Zhang, Shiqiang;Lin, Zhao;Qi, Mingfu;Wan, Shengqing;Xie, Liangfu;Fan, Fan;Nickerson, Michael L;Zou, Xiangjun;Hu, Xueda;Xing, Li;Lv, Zhaojie;Mei, Hongbin;Gao, Shengjie;Liang, Chaozhao;Gao, Zhibo;Lu, Jingxiao;Yu, Yuan;Liu, Chunxiao;Li, Lin;Fang, Xiaodong;Jiang, Zhimao;Yang, Jie;Li, Cailing;Zhao, Xin;Chen, Jing;Zhang, Fang;Lai, Yongqi;Lin, Zheguang;Zhou, Fangjian;Chen, Hao;Chan, Hsiao Chang;Tsang, Shirley;Theodorescu, Dan;Li, Yingrui;Zhang, Xiuqing;Wang, Jian;Yang, Huanming;Gui, Yaoting;Wang, Jun;Cai, Zhiming*
通讯作者:
Cai, Zhiming
作者机构:
[Zou, Xiangjun; Sun, Xiaojuan; Xie, Liangfu; Wu, Song; Qi, Mingfu; Tang, Aifa; Lv, Zhaojie; Chen, Hao; Li, Zesong; Xing, Li; Cai, Zhiming; Guo, Guangwu; Zhang, Shiqiang; Huang, Yi; Mei, Hongbin] Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Dept Urol Surg, Shenzhen, Peoples R China.
[Li, Lin; Wan, Shengqing; Yang, Zuoquan; Fan, Fan; Zhang, Fang; Chen, Chao; Gao, Shengjie; Ye, Rui; Jia, Wenlong; Yu, Yuan; Yang, Huanming; Zhang, Xiuqing; Zhao, Xin; Fang, Xiaodong; Lin, Zhao; Huang, Peide; Hu, Xueda; Gao, Zhibo; Zhou, Quan; Wang, Jian; Guo, Guangwu; Wang, Jun; Li, Yingrui; Song, Pengfei; Yang, Jie] BGI Shenzhen, Shenzhen, Peoples R China.
[Zou, Xiangjun; Sun, Xiaojuan; Xie, Liangfu; Wu, Song; Qi, Mingfu; Tang, Aifa; Lv, Zhaojie; Chen, Hao; Li, Zesong; Xing, Li; Cai, Zhiming; Zhang, Shiqiang; Huang, Yi; Mei, Hongbin] Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Natl Reg Key Technol Engn Lab Clin Applicat Canc, Shenzhen, Peoples R China.
[Zou, Xiangjun; Sun, Xiaojuan; Xie, Liangfu; Wu, Song; Qi, Mingfu; Tang, Aifa; Lv, Zhaojie; Chen, Hao; Li, Zesong; Xing, Li; Cai, Zhiming; Zhang, Shiqiang; Huang, Yi; Mei, Hongbin] Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen Engn Lab Tumor Clin Immune Gene Therapy, Shenzhen, Peoples R China.
[Zou, Xiangjun; Sun, Xiaojuan; Xie, Liangfu; Wu, Song; Qi, Mingfu; Tang, Aifa; Lv, Zhaojie; Chen, Hao; Li, Zesong; Xing, Li; Cai, Zhiming; Zhang, Shiqiang; Huang, Yi; Mei, Hongbin] Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen Key Lab Genitourinary Tumor, Shenzhen, Peoples R China.
通讯机构:
[Cai, Zhiming] Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Dept Urol Surg, Shenzhen, Peoples R China.
语种:
英文
期刊:
Nature Genetics
ISSN:
1061-4036
年:
2013
卷:
45
期:
12
页码:
1459-1463
文献类别:
WOS:Article
所属学科:
ESI学科类别:分子生物学&遗传学;WOS学科类别:Genetics & Heredity
入藏号:
基金类别:
Chinese High-Tech (863) Program [2012AA02A201, 2012AA02A208]; Guangdong Innovative Research Team Program [2009010016]; State Key Development Program for Basic Research of China-973 Program [2011CB809203, 2014CB745200]; Shenzhen Municipal Government of China [JC201005260191A, CXB201108250096A, ZDSY20120615154448514, BGI20100001]
机构署名:
本校为其他机构
院系归属:
湘雅二医院(第二临床学院)
摘要:
Bladder cancer is one of the most common cancers worldwide, with transitional cell carcinoma (TCC) being the predominant form. Here we report a genomic analysis of TCC by both whole-genome and whole-exome sequencing of 99 individuals with TCC. Beyond confirming recurrent mutations in genes previously identified as being mutated in TCC, we identified additional altered genes and pathways that were implicated in TCC. Notably, we discovered frequent alterations in STAG2 and ESPL1, two genes involved in the sister chromatid cohesion and segregation (SCCS) process. Furthermore, we also detected a recurrent fusion involving FGFR3 and TACC3, another component of SCCS, by transcriptome sequencing of 42 DNA-sequenced tumors. Overall, 32 of the 99 tumors (32%) harbored genetic alterations in the SCCS process. Our analysis provides evidence that genetic alterations affecting the SCCS process may be involved in bladder tumorigenesis and identifies a new therapeutic possibility for bladder cancer.
参考文献:
Jemal, A. et al. Global cancer statistics. CA Cancer J. Clin. 61, 69–90 (2011).
Wu, X.R. Urothelial tumorigenesis: a tale of divergent pathways. Nat. Rev. Cancer 5, 713–725 (2005).
Gui, Y. et al. Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat. Genet. 43, 875–878 (2011).
Cordon-Cardo, C. et al. p53 mutations in human bladder cancer: genotypic versus phenotypic patterns. Int. J. Cancer 56, 347–353 (1994).
Jebar, A.H. et al. FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma. Oncogene 24, 5218–5225 (2005).

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