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Overexpression long non-coding RNA LINC00673 is associated with poor prognosis and promotes invasion and metastasis in tongue squamous cell carcinoma.

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WOS被引频次:43
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成果类型:
期刊论文
作者:
Yu, Jianjun;Liu, Yan;Gong, Zhaojian;Zhang, Shanshan;Guo, Can;Li, Xiayu;Tang, Yanyan;Yang, Liting;He, Yi;Wei, Fang;Wang, Yumin;Liao, Qianjin;Zhang, Wenling;Li, Xiaoling;Li, Yong;Li, Guiyuan;Xiong, Wei*;Zeng, Zhaoyang*
通讯作者:
Xiong, Wei;Zeng, Zhaoyang
作者机构:
[He, Yi; Li, Xiaoling; Yu, Jianjun; Zeng, Zhaoyang; Xiong, W; Xiong, Wei; Liu, Yan; Liao, Qianjin; Li, Guiyuan] Cent S Univ, Sch Med, Hunan Canc Hosp, Dept Head & Neck Surg, Changsha, Hunan, Peoples R China.
[He, Yi; Li, Xiaoling; Yu, Jianjun; Zeng, Zhaoyang; Xiong, W; Xiong, Wei; Liu, Yan; Liao, Qianjin; Li, Guiyuan] Cent S Univ, Sch Med, Affiliated Canc Hosp, Changsha, Hunan, Peoples R China.
[He, Yi; Gong, Zhaojian; Wei, Fang; Zhang, Wenling; Li, Xiaoling; Zeng, Zhaoyang; Wang, Yumin; Guo, Can; Li, Yong; Yang, Liting; Xiong, W; Xiong, Wei; Liu, Yan; Liao, Qianjin; Tang, Yanyan; Li, Xiayu; Li, Guiyuan] Cent S Univ, Canc Res Inst, Key Lab Carcinogenesis, Chinese Minist Hlth, Changsha, Hunan, Peoples R China.
[Gong, Zhaojian; Li, Xiaoling; Zeng, Zhaoyang; Wang, Yumin; Xiong, W; Xiong, Wei; Zhang, Shanshan; Li, Guiyuan] Cent S Univ, Xiangya Hosp, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Changsha, Hunan, Peoples R China.
[Gong, Zhaojian] Cent S Univ, Xiangya Hosp 2, Dept Stomatol, Changsha, Hunan, Peoples R China.
通讯机构:
[Xiong, W; Zeng, ZY] Cent S Univ, Sch Med, Hunan Canc Hosp, Dept Head & Neck Surg, Changsha, Hunan, Peoples R China.
[Xiong, W; Zeng, ZY] Cent S Univ, Sch Med, Affiliated Canc Hosp, Changsha, Hunan, Peoples R China.
[Xiong, W; Zeng, ZY] Cent S Univ, Canc Res Inst, Key Lab Carcinogenesis, Chinese Minist Hlth, Changsha, Hunan, Peoples R China.
[Xiong, W; Zeng, ZY] Cent S Univ, Xiangya Hosp, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Changsha, Hunan, Peoples R China.
语种:
英文
关键词:
long non-coding RNA (lncRNA);long intergenic non-coding RNA 673 (LINC00673);tongue squamous cell carcinoma (TSCC);prognosis;metastasis
期刊:
Oncotarget
年:
2016
卷:
8
期:
10
页码:
16621-16632
文献类别:
WOS:Article
所属学科:
ESI学科类别:分子生物学&遗传学;WOS学科类别:Cell Biology;Oncology
入藏号:
WOS:000396024600044;PMID:28039470
基金类别:
National Natural Science Foundation of China [81372907, 81301757, 81472531, 81402009, 81572787, 81672683]; Natural Science Foundation of Hunan Province [14JJ1010, 2015JJ1022]
机构署名:
本校为第一且通讯机构
院系归属:
基础医学院
口腔医学院(湘雅口腔医院)
湘雅医院(第一临床学院)
湘雅二医院(第二临床学院)
湘雅三医院(第三临床学院)
摘要:
Long non-coding RNAs (lncRNAs) associated with the tumorigenesis of human cancers. However, the relevance of lncRNAs in tongue squamous cell carcinoma (TSCC) is still unclear. To discover novel TSCC-related lncRNAs, we analyzed the lncRNA expression patterns in two sets of TSCC gene expression profile data, and found that long intergenic non-coding RNA 673 (LINC00673) was significantly upregulated in TSCC samples. Then we examined LINC00673 expression in 202 TSCC tissue specimens, LINC00673 is highly expressed in a significant proportion of human TSCC biopsies and correlates with poor prognosis. Knockdown LINC00673 significantly inhibited the cell invasion and migration capability in TSCC cells. Our findings suggest that LINC00673 may play an essential role in TSCC progression and might serve as a potential biomarker for early detection and prognosis prediction of TSCC.
参考文献:
Argiris A, 2003, CANC TREAT, V114, P15
Bo H, 2015, ONCOTARGET, V6, P20404, DOI 10.18632/oncotarget.4057
Chang L, 2016, MOL MED REP, V13, P1541, DOI 10.3892/mmr.2015.4716
Chen C, 2008, CANCER EPIDEM BIOMAR, V17, P2152, DOI 10.1158/1055-9965.EPI-07-2893
Duan Z, 2014, CELL MOL IMMUNOL, V11, P197, DOI 10.1038/cmi.2013.52

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