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Cell Membrane Camouflaged Hollow Prussian Blue Nanoparticles for Synergistic Photothermal‐/Chemotherapy of Cancer

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WOS被引频次:66
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成果类型:
期刊论文
作者:
Chen, Wansong;Zeng, Ke;Liu, Hong;Ouyang, Jiang;Wang, Liqiang;Liu, Ying;Wang, Hao;Deng, Liu*;Liu, You-Nian*
通讯作者:
Liu, You-Nian;Deng, Liu
作者机构:
[Chen, Wansong; Liu, You-Nian] Cent S Univ, State Key Lab Powder Met, Changsha 410083, Hunan, Peoples R China.
[Liu, Ying; Zeng, Ke; Chen, Wansong; Deng, Liu; Liu, You-Nian; Ouyang, Jiang; Wang, Liqiang] Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.
[Liu, Hong; Wang, Hao] Cent S Univ, Aier Ophthalm Coll, Changsha 410083, Hunan, Peoples R China.
通讯机构:
[Liu, You-Nian] Cent S Univ, State Key Lab Powder Met, Changsha 410083, Hunan, Peoples R China.
[Deng, L; Liu, YN] Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.
语种:
英文
关键词:
cell membrane;chemotherapy;combination therapy;hollow Prussian blue nanoparticles;photothermal therapy
期刊:
Advanced Functional Materials
ISSN:
1616-301X
年:
2017
卷:
27
期:
11
页码:
-
文献类别:
WOS:Article;EI:Journal article (JA)
所属学科:
ESI学科类别:材料科学;WOS学科类别:Chemistry, Multidisciplinary;Chemistry, Physical;Materials Science, Multidisciplinary;Nanoscience & Nanotechnology;Physics, Applied;Physics, Condensed Matter
入藏号:
WOS:000397348100020;EI:20170703339486
基金类别:
National Natural Science Foundation of China [21636010, 21476266]; State Key Laboratory of Powder Metallurgy, Central South University, Changsha, China
机构署名:
本校为第一且通讯机构
院系归属:
化学化工学院
爱尔眼科学院
粉末冶金研究院
摘要:
Nanodrug‐based cancer therapy has been actively developed in the past decades. The main challenges faced by nanodrugs include poor drug loading capacity, rapid clearance from blood circulation, and low antitumor efficiency with high risk of recurrence. In this work, red blood cell (RBC) membrane camouflaged hollow mesoporous Prussian blue nanoparticles (HMPB@RBC NPs) are fabricated for combination therapy of cancer. The stability, immune evading capacity, and blood retention time of HMPB@RBC NPs are significantly enhanced compared with those of bare HMPB NPs. Doxorubicin (DOX), as a model drug is encapsulated within HMPB@RBC NPs with loading capacity up to 130% in weight. In addition, DOX loaded HMPB@RBC NPs show pH‐/photoresponsive release. The in vivo studies demonstrate the outstanding performance of DOX@HMPB@RBC NPs in synergistic photothermal‐/chemotherapy of cancer.
参考文献:
Cai XJ, 2015, ADV MATER, V27, P6382, DOI 10.1002/adma.201503381
Cai XJ, 2015, ADV FUNCT MATER, V25, P2520, DOI 10.1002/adfm.201403991
Chen WS, 2017, ADV MATER, V29, DOI 10.1002/adma.201603864
Chen WS, 2016, NANOSCALE, V8, P10364, DOI 10.1039/c6nr00535g
Chen WS, 2015, CHEM COMMUN, V51, P9193, DOI 10.1039/c5cc02508g

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