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Programmable Engineering of a Biosensing Interface with Tetrahedral DNA Nanostructures for Ultrasensitive DNA Detection

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WOS被引频次:102
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成果类型:
期刊论文
作者:
Lin, Meihua;Wang, Jingjing;Zhou, Guobao;Wang, Jianbang;Wu, Na;Lu, Jianxin;Gao, Jimin;Chen, Xiaoqing;Shi, Jiye;Zuo, Xiaolei*;Fan, Chunhai
通讯作者:
Zuo, Xiaolei
作者机构:
[Shi, Jiye; Zhou, Guobao; Lin, Meihua; Wang, Jingjing; Wang, Jianbang; Fan, Chunhai; Wu, Na; Zuo, Xiaolei] Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.
[Shi, Jiye; Zhou, Guobao; Lin, Meihua; Wang, Jingjing; Wang, Jianbang; Fan, Chunhai; Wu, Na; Zuo, Xiaolei] Chinese Acad Sci, Bioimaging Ctr, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China.
[Lu, Jianxin; Wang, Jianbang; Gao, Jimin] Wenzhou Med Univ, Sch Med Lab Sci & Life Sci, Wenzhou 325035, Zhejiang, Peoples R China.
[Zhou, Guobao; Chen, Xiaoqing] Cent S Univ, Sch Chem & Chem Engn, Collaborat Innovat Ctr Resource Conserving & Envi, Changsha 410083, Hunan, Peoples R China.
[Shi, Jiye] UCB Pharma, Slough SL1 4EN, Berks, England.
通讯机构:
[Zuo, Xiaolei] Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.
语种:
英文
关键词:
biosensors;DNA nanostructures;electrochemistry;soft lithography;surface chemistry
期刊:
Angewandte Chemie International Edition
ISSN:
1521-3773
年:
2015
卷:
54
期:
7
页码:
2151-2155
文献类别:
WOS:Article;EI:Journal article (JA)
所属学科:
ESI学科类别:化学;WOS学科类别:Chemistry, Multidisciplinary
入藏号:
WOS:000349391000023;EI:20150700515362
基金类别:
National Basic Research Program (973 Program) [2012CB932600, 2013CB932803]; NSFC [91313302, 21390414, 21422508, 21329501]; Shanghai Pujiang Project [13PJ1410700]; Chinese Academy of Sciences
机构署名:
本校为其他机构
院系归属:
商学院
化学化工学院
摘要:
Self‐assembled DNA nanostructures with precise sizes allow a programmable “soft lithography” approach to engineer the interface of electrochemical DNA sensors. By using millimeter‐sized gold electrodes modified with several types of tetrahedral DNA nanostructures (TDNs) of different sizes, both the kinetics and thermodynamics of DNA hybridization were profoundly affected. Because each DNA probe is anchored on an individual TDN, its lateral spacing and interactions are finely tuned by the TDN size. By simply varying the size of the TDNs, the hybridization time was decreased and the hybridization efficiency was increased. More significantly, the detection limit for DNA detection was tuned over four orders of magnitude with differentially nanostructured electrodes, and achieved attomolar sensitivity with polymeric enzyme amplification.
参考文献:
Abel GR, 2013, J AM CHEM SOC, V135, P6399, DOI 10.1021/ja401036t
[Anonymous], 2010, ANGEW CHEM, V122, P2760
[Anonymous], 2013, ANGEW CHEM, V125, P9896
Bin XM, 2010, ANAL CHEM, V82, P5928, DOI 10.1021/ac101164n
Chin CD, 2011, NAT MED, V17, P1015, DOI 10.1038/nm.2408

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