版权说明 帮助中心
首页 > 成果 > 详情

Exposure to outdoor air pollution during trimesters of pregnancy and childhood asthma, allergic rhinitis, and eczema

ESI高被引SCI-EMedline
WOS被引频次:61
认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Deng, Qihong*;Lu, Chan;Li, Yuguo;Sundell, Jan;Norback, Dan
通讯作者:
Deng, Qihong
作者机构:
[Sundell, Jan; Lu, Chan; Norback, Dan; Deng, Qihong] Cent S Univ, Sch Energy Sci & Engn, Changsha 410083, Hunan, Peoples R China.
[Deng, Qihong] Cent S Univ, Sch Publ Hlth, Changsha 410083, Hunan, Peoples R China.
[Deng, Qihong] Cent S Univ, Inst Environm Hlth, Changsha 410083, Hunan, Peoples R China.
[Li, Yuguo] Univ Hong Kong, Dept Mech Engn, Hong Kong, Hong Kong, Peoples R China.
[Sundell, Jan] Tsinghua Univ, Sch Architecture, Beijing, Peoples R China.
通讯机构:
[Deng, Qihong] Cent S Univ, Sch Energy Sci & Engn, Changsha 410083, Hunan, Peoples R China.
语种:
英文
关键词:
Allergy;Traffic-related air pollution;Fetal origins;Prenatal exposure;Multi- pollutant and trimester model
期刊:
Environmental Research
ISSN:
0013-9351
年:
2016
卷:
150
页码:
119-127
文献类别:
WOS:Article
所属学科:
ESI学科类别:环境科学/生态学;WOS学科类别:Environmental Sciences;Public, Environmental & Occupational Health
入藏号:
基金类别:
National Natural Science Foundation of China [51178466, 51576214]
机构署名:
本校为第一且通讯机构
院系归属:
冶金与环境学院
湘雅公共卫生学院
能源科学与工程学院
摘要:
Background: Mounting evidence suggests that exposure to ambient air pollution is associated with the development of childhood allergic diseases, but the effect of prenatal exposure to air pollution on the risk of childhood asthma and allergy is unclear. Objectives: We evaluated the association between maternal exposure to outdoor air pollution during different trimesters of pregnancy and incidence of asthma, allergic rhinitis, and eczema in 2598 preschool children aged 3-6 years in China. Methods: Children's lifetime incidence of allergic diseases was obtained using questionnaire. Individual exposure to outdoor air pollutants during trimesters of pregnancy was estimated by an inverse distance weighted (IDW) method based on the measured concentrations at monitoring stations. We used multiple logistic regression method to estimate the odds ratio (OR) of asthma, allergic rhinitis, and eczema for per interquartile range (IQR) increase in the exposure to air pollutant in each trimester, which was adjusted for the effect of other air pollutants and its effect in other trimesters by a multi-pollutant/trimester model. Results: Incidence of asthma (6.8%), allergic rhinitis (7.3%), and eczema (28.6%) in children was associated with maternal exposure to traffic-related pollutant NO2 during entire pregnancy with OR (95% confidence interval [CID respectively 1.63 (0.99-2.70), 1.69 (1.03-2.77), and 1.37 (1.04-1.80). After adjustment for other pollutants and trimesters, we found the association was significant only in specific trimester: the first trimester for eczema (1.54, 1.14-2.09), the second trimester for asthma (1.72, 1.02-2.97), and the third trimester for allergic rhinitis (1.77, 1.09-2.89). Sensitivity analysis indicated that the trimester sensitive to the development of allergic diseases was stable. Conclusion: Maternal exposure to traffic-related air pollutant NO2 during pregnancy, especially in specific trimesters, is associated with an increased risk of developing asthma, rhinitis, and eczema in children. Our results support the hypothesis that childhood allergic diseases originate in fetal life and are triggered by traffic-related air pollution in sensitive trimesters. (C) 2016 Elsevier Inc. All rights reserved.
参考文献:
Aguilera I, 2013, ENVIRON HEALTH PERSP, V121, P387, DOI 10.1289/ehp.1205281
Ahn K, 2014, J ALLERGY CLIN IMMUN, V134, P993, DOI 10.1016/j.jaci.2014.09.023
Ait-Khaled N, 2007, ALLERGY, V62, P230, DOI 10.1111/j.1398-9995.2007.01326.x
Asher MI, 2006, LANCET, V368, P733, DOI 10.1016/S0140-6736(06)69283-0
BARKER DJP, 1986, LANCET, V1, P1077

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com